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neuroligin 3

Summary

Gene Symbol

Nlgn3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

245537

PubChem

245537

Alliance of Genome Resources

MGI:2444609

Annotation

Keyword

3D-structure
Cell adhesion
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BYM5	Gliotactin homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 41 in total

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GO Term	Evidence Code	PMID
adult behavior	ISO
regulation of NMDA receptor activity	IMP	21808020
negative regulation of excitatory postsynaptic potential	IMP	21808020
positive regulation of inhibitory postsynaptic potential	ISO
presynaptic membrane assembly	IBA ISO ISS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell adhesion [inference]

cell-cell adhesion [inference]

neuron cell-cell adhesion

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

oligodendrocyte differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

postsynaptic specialization assembly

postsynaptic specialization organization [inference]

postsynaptic specialization assembly

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

organelle assembly [inference]

postsynaptic specialization assembly

membrane assembly [inference]

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization

synapse assembly

membrane organization [inference]

postsynaptic membrane organization [inference]

postsynaptic membrane assembly

membrane assembly [inference]

presynaptic membrane organization [inference]

presynaptic membrane assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

regulation of respiratory gaseous exchange by nervous system process

cognition [inference]

learning or memory [inference]

learning

associative learning [inference]

visual learning

behavior [inference]

learning or memory [inference]

learning

associative learning [inference]

visual learning

rhythmic behavior [inference]

circadian behavior [inference]

circadian sleep/wake cycle

visual behavior [inference]

visual learning

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

oligodendrocyte differentiation

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

rhythmic process [inference]

circadian rhythm [inference]

circadian behavior [inference]

circadian sleep/wake cycle

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

modulation of excitatory postsynaptic potential [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic

positive regulation of synaptic transmission, glutamatergic

rhythmic synaptic transmission

modulation of excitatory postsynaptic potential [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of synaptic vesicle clustering

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

positive regulation of protein localization to synapse

positive regulation of protein localization [inference]

positive regulation of protein localization to synapse

regulation of synaptic vesicle clustering [inference]

positive regulation of synaptic vesicle clustering

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to synapse

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of synaptic vesicle clustering

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of dendritic spine development

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of inhibitory postsynaptic potential

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

negative regulation of developmental process [inference]

negative regulation of dendritic spine development [inference]

negative regulation of dendritic spine morphogenesis

negative regulation of excitatory postsynaptic potential

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

modulation of excitatory postsynaptic potential [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendritic spine morphogenesis

negative regulation of dendritic spine morphogenesis

negative regulation of developmental process [inference]

negative regulation of dendritic spine development [inference]

negative regulation of dendritic spine morphogenesis

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of dendritic spine development

regulation of dendritic spine development [inference]

positive regulation of dendritic spine development

negative regulation of dendritic spine development [inference]

negative regulation of dendritic spine morphogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

modulation of excitatory postsynaptic potential [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

regulation of glutamate receptor signaling pathway [inference]

positive regulation of glutamate receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity [inference]

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic

positive regulation of synaptic transmission, glutamatergic

rhythmic synaptic transmission

modulation of excitatory postsynaptic potential [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of synaptic transmission [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to synapse

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

regulation of dendritic spine morphogenesis

negative regulation of dendritic spine morphogenesis

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of presynapse organization [inference]

regulation of terminal button organization

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis

negative regulation of dendritic spine morphogenesis

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of dendritic spine morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

positive regulation of protein localization to synapse

positive regulation of protein localization [inference]

positive regulation of protein localization to synapse

regulation of multicellular organismal process [inference]

regulation of respiratory gaseous exchange [inference]

regulation of respiratory system process [inference]

regulation of respiratory gaseous exchange by nervous system process

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of inhibitory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

regulation of respiratory system process [inference]

regulation of respiratory gaseous exchange by nervous system process

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of inhibitory postsynaptic potential

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

regulation of synaptic plasticity [inference]

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of AMPA receptor activity

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of AMPA receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of AMPA receptor activity

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
inhibitory synapse	ISO
postsynaptic membrane	ISO ISS
endocytic vesicle	ISO ISS
presynapse
postsynaptic specialization membrane	IBA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

cell body [inference]

neuronal cell body

presynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
neurexin family protein binding	IBA ISO ISS
signaling receptor activity	IBA ISO
scaffold protein binding	ISO
cell adhesion molecule binding	ISO ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

neurexin family protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

neuroligin-3

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
chemical synaptic transmission
membrane assembly
modulation of chemical synaptic transmission
neuron cell-cell adhesion
postsynaptic membrane assembly
presynaptic membrane assembly
regulation of localization
regulation of membrane potential
regulation of nervous system process
synapse assembly

Displaying **all 4** entries
InterPro
Alpha/Beta hydrolase fold
Carboxylesterase type B, conserved site
Carboxylesterase, type B
Neuroligin

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **117** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33962		FB:FBgn0031866
Drosophila melanogaster	37854		FB:FBgn0034972
Drosophila melanogaster	40912		FB:FBgn0083963
Drosophila melanogaster	40913		FB:FBgn0051146
Drosophila melanogaster	42402		FB:FBgn0083975
Homo sapiens	54413		HGNC:14289	HUMAN101151
Rattus norvegicus	171297	10116_1:0054c0	RGD:621119	RATNO45435
Caenorhabditis elegans	181484		WB:WBGene00006412
Pan troglodytes	473660			PANTR46245
Canis lupus familiaris	491947			CANLF19872

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements