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alpha-L-fucosidase 2

Summary

Gene Symbol

FUCA2

Aliases

MGC1314
a-L-fucosidase 2
dJ20N2.5
plasma fucosidase
α-L-fucosidase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2519

HGNC

4008

KEGG Gene ID

hsa:2519

PubChem

2519

Alliance of Genome Resources

HGNC:4008

Annotation

Keyword

Alternative splicing
Glycoprotein
Glycosidase
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BTY2	Alpha-L-fucoside fucohydrolase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
regulation of entry of bacterium into host cell	IMP	19666478
glycoside catabolic process	IBA IDA	19666478
response to bacterium	IMP	19666478
fucose metabolic process	IBA IDA	19666478

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

glycoside catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

glycoside catabolic process

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

glycoside catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

organic substance catabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

glycoside catabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of entry of bacterium into host cell

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	TAS
extracellular region	TAS
extracellular space	IDA	19666478
extracellular exosome	HDA	23533145
lysosome	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
alpha-L-fucosidase activity	IBA IDA	19666478
protein binding	IPI	25416956 31515488 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

fucosidase activity [inference]

alpha-L-fucosidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01206

Name

alpha-L-fucosidase [EC:3.2.1.51]

References

Rhea

RHEA:12288

H₂O + an α-L-fucoside

L-fucose + an alcohol

Enzyme

3.2.1.51

PMID

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:10923	sickle cell anemia	DisGeNET
DOID:1724	duodenal ulcer	DisGeNET
DOID:2914	immune system disease	DisGeNET
DOID:3343	glycoproteinosis	DisGeNET
DOID:417	autoimmune disease	DisGeNET
DOID:5419	schizophrenia	DisGeNET
DOID:6688	autoimmune lymphoproliferative syndrome	DisGeNET

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	189173	WB:WBGene00012225
Drosophila melanogaster	3772574	FB:FBgn0285958
Ciona intestinalis	100184076		CIOIN05563
Latimeria chalumnae	102364174		LATCH01888
Danio rerio	445487	ZFIN:ZDB-GENE-040822-39	DANRE11941
Astyanax mexicanus	103032153		ASTMX08160
Ictalurus punctatus	108270046		ICTPU35647
Electrophorus electricus	113572634		ELEEL13399
Salmo trutta	115172225		SALTR72781
Gadus morhua	115543804		GADMO49451

GlyTouCan

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GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements