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cystatin C

Summary

Gene Symbol

Cst3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25307

PubChem

25307

Alliance of Genome Resources

RGD:2432

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal
Thiol protease inhibitor

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6K7D9
P14841	Cystatin-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 26 in total

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GO Term	Evidence Code	PMID
negative regulation of elastin catabolic process	ISO
defense response	ISO
negative regulation of blood vessel remodeling	ISO
response to axon injury	IEP	12044447 14745560 8738161 9147287
response to estradiol	IEP	16935259

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

Sertoli cell development

embryo implantation

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

Sertoli cell development

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

animal organ development [inference]

sensory organ development [inference]

eye development

gonad development [inference]

male gonad development

gland development [inference]

salivary gland development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

Sertoli cell development

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to wounding [inference]

response to axon injury

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate

response to organic cyclic compound

response to estradiol

response to lipid [inference]

response to estradiol

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of collagen catabolic process [inference]

negative regulation of collagen catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of glycoprotein metabolic process [inference]

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of glycoprotein metabolic process [inference]

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

regulation of glycoprotein metabolic process [inference]

regulation of elastin catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of collagen metabolic process [inference]

negative regulation of collagen catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of glycoprotein metabolic process [inference]

negative regulation of elastin catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

negative regulation of developmental process [inference]

negative regulation of blood vessel remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of tissue remodeling [inference]

negative regulation of blood vessel remodeling

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of blood vessel remodeling [inference]

negative regulation of blood vessel remodeling

negative regulation of developmental process [inference]

negative regulation of blood vessel remodeling

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

negative regulation of extracellular matrix disassembly

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of multicellular organismal process [inference]

regulation of tissue remodeling

negative regulation of tissue remodeling [inference]

negative regulation of blood vessel remodeling

regulation of blood vessel remodeling [inference]

negative regulation of blood vessel remodeling

negative regulation of multicellular organismal process [inference]

negative regulation of tissue remodeling [inference]

negative regulation of blood vessel remodeling

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
axon	IDA	14738488
nuclear membrane	IDA	15872057
cytoplasm	IBA
plasma membrane	ISO
extracellular space	IBA IDA ISO	2689174

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular non-membrane-bounded organelle [inference]

contractile fiber

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cysteine-type endopeptidase inhibitor activity	IBA IEA ISO TAS	16140167 2689174
endopeptidase inhibitor activity	ISO
amyloid-beta binding	ISO
peptidase inhibitor activity	IDA ISO	8761177
protease binding	IDA ISO	2622871 8761177

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

identical protein binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cystatin-C

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription

Displaying **all 3** entries
InterPro
Cystatin domain
Cystatin superfamily
Proteinase inhibitor I25, cystatin, conserved site

Alliance of Genome Resources

Expression

Displaying **all 10** entries
Location	References
nuclear membrane	PMID:15872057
neuronal cell body	PMID:14738488
perinuclear region of cytoplasm	PMID:16414118
vesicle	PMID:10950881
axon	PMID:14738488
extracellular space	PMID:2689174
multivesicular body	PMID:10950881
cell projection	PMID:16309830
contractile muscle fiber	PMID:8245434
basement membrane	PMID:15872057

Disease

Disease Ontology

Displaying entries **1 - 10** of 16 in total

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DO ID	Disease Name	Source
DOID:0070027	CST3-related cerebral amyloid angiopathy	Alliance of Genome Resources
DOID:0110023	age related macular degeneration 11	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10941	intracranial aneurysm	Alliance of Genome Resources
DOID:11758	iron deficiency anemia	Alliance of Genome Resources
DOID:12842	Guillain-Barre syndrome	Alliance of Genome Resources
DOID:1389	polyneuropathy	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **115** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1471		HGNC:2475	HUMAN56320
Mus musculus	13010	10090_1:000836	MGI:102519	MOUSE35927
Caenorhabditis elegans	177372		WB:WBGene00000535
Bos taurus	281102			BOVIN04610
Danio rerio	566959		ZFIN:ZDB-GENE-060810-77	DANRE05494
Macaca mulatta	574313			MACMU01489
Canis lupus familiaris	607874			CANLF08893
Sus scrofa	733672			PIGXX11369
Pan troglodytes	743081			PANTR24509
Danio rerio	791878		ZFIN:ZDB-GENE-030131-373

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LM-GlycoRepo

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Acknowledgements