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kallikrein related-peptidase 8

Summary

Gene Symbol

Klk8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

259277

PubChem

259277

Alliance of Genome Resources

MGI:1343327

Annotation

Keyword

3D-structure
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0B6VRH9
Q61955	Neuropsin Serine protease 19

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
proteolysis	IEA
memory	IMP	16308352
response to wounding	IDA	10196465 10421059 11274744
keratinocyte proliferation	IMP	17182622
neuron projection morphogenesis	IDA	11880192

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cellular process [inference]

cell population proliferation [inference]

epithelial cell proliferation [inference]

keratinocyte proliferation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

cell junction organization [inference]

synapse organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

response to stimulus [inference]

response to stress [inference]

response to wounding

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of synapse organization

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	9556608
extracellular space	IBA
cytoplasm	ISO
cytoplasm	IDA	17761692
secretory granule	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

peptidase inhibitor complex [inference]

protease inhibitor complex [inference]

serine protease inhibitor complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IDA	12944500 9556608
serine-type endopeptidase activity	IBA
peptidase activity	IDA	28267150
peptidase activity	IMP	28267150

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

kallikrein-8

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 6** entries
Gene Ontology
hydrolase activity
memory
neuron projection morphogenesis
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	354	FB:FBgn0052808
Drosophila melanogaster	3816	FB:FBgn0052808
Drosophila melanogaster	3817	FB:FBgn0052808
Drosophila melanogaster	5653	FB:FBgn0052808
Drosophila melanogaster	11012	FB:FBgn0052808
Homo sapiens	11202	HGNC:6369	HUMAN45433
Drosophila melanogaster	13646	FB:FBgn0052808
Drosophila melanogaster	13647	FB:FBgn0052808
Drosophila melanogaster	13648	FB:FBgn0052808
Drosophila melanogaster	16612	FB:FBgn0052808

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements