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ER degradation enhancer, mannosidase alpha-like 2

Summary

Gene Symbol

Edem2

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

34714

PubChem

34714

Alliance of Genome Resources

FB:FBgn0032480

Annotation

Keyword

Calcium
Endoplasmic reticulum
Glycosidase
Metal-binding
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9VK27
M9PCV1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
mannoprotein catabolic process	IBA
endoplasmic reticulum unfolded protein response	IMP	25716426
endoplasmic reticulum unfolded protein response	IGI	19805114
endoplasmic reticulum unfolded protein response	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

macromolecule modification [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to glycoprotein [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to glycoprotein [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to oxygen-containing compound [inference]

response to glycoprotein [inference]

ubiquitin-dependent glycoprotein ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response

ERAD pathway

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	25716426
endoplasmic reticulum	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	ISM	19805114
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IBA
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA
calcium ion binding	IEA
unfolded protein binding	IPI	19805114

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity [inference]

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

binding [inference]

protein binding [inference]

unfolded protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mannosyl-oligosaccharide

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
calcium ion binding
hydrolase activity, acting on glycosyl bonds
hydrolase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
metal ion binding

Displaying **all 3** entries
InterPro
Glycoside hydrolase family 47
Seven-hairpin glycosidases
Six-hairpin glycosidase-like superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
endoplasmic reticulum	PMID:25716426
membrane	FB:FBrf0231198

Ortholog

Displaying **all 9** entries
Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	9695	SGD:S000001247
Xenopus tropicalis	34714	Xenbase:XB-GENE-5811499
Xenopus tropicalis	66967	Xenbase:XB-GENE-5811499
Xenopus tropicalis	80267	Xenbase:XB-GENE-5811499
Saccharomyces cerevisiae S288C	177857	SGD:S000001247
Xenopus tropicalis	181210	Xenbase:XB-GENE-5811499
Saccharomyces cerevisiae S288C	192193	SGD:S000001247
Xenopus tropicalis	443907	Xenbase:XB-GENE-5811499
Saccharomyces cerevisiae S288C	856611	SGD:S000001247

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OrthoDB (Group)

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Acknowledgements