GlyCosmos Portal

Submissions

torso

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

35717

PubChem

35717

Alliance of Genome Resources

FB:FBgn0003733

Annotation

Keyword

ATP-binding
Alternative splicing
Developmental protein
Glycoprotein
Magnesium
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
P18475

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
negative regulation of hippo signaling	IMP	26474042
negative phototaxis	IMP	24009394
negative regulation of multicellular organism growth	IMP	23959885
germ cell migration	IMP	14602078
chorion-containing eggshell pattern formation	HMP	1783295

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

torso signaling pathway

cellular process involved in reproduction in multicellular organism [inference]

cellular developmental process [inference]

cell fate determination [inference]

pole cell fate determination

cell motility [inference]

cell migration [inference]

germ cell migration

reproductive process [inference]

developmental process involved in reproduction [inference]

cellular process involved in reproduction in multicellular organism [inference]

multicellular organismal process [inference]

multicellular organism development

metamorphosis

pattern specification process [inference]

regionalization [inference]

chorion-containing eggshell pattern formation

embryonic pattern specification [inference]

terminal region determination

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

anatomical structure development [inference]

multicellular organism development

metamorphosis

cellular developmental process [inference]

cell fate determination [inference]

pole cell fate determination

locomotion [inference]

taxis [inference]

energy taxis [inference]

phototaxis [inference]

negative phototaxis

negative energy taxis [inference]

negative phototaxis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

phototaxis [inference]

negative phototaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

torso signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

Displaying **all 2** entries
GO Term	Evidence Code	PMID
receptor complex	IBA
plasma membrane	IBA IDA	28087630 28743001

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	9885560
metal ion binding
transmembrane receptor protein tyrosine kinase activity	IBA IDA IMP	1333890 28087630 8423783 8598287 9885560 9892666
protein tyrosine kinase activity	IEA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying **all 5** entries
InterPro
Protein kinase domain
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, active site
Tyrosine-protein kinase, catalytic domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
plasma membrane	PMID:28087630 PMID:28743001

Disease

Disease Ontology

Displaying entries **1 - 10** of 45 in total

1

2

3

4

5

Next ›

Last »
DO ID	Disease Name	Source
DOID:0050580	hereditary lymphedema	Alliance of Genome Resources
DOID:0050792	multiple cutaneous and mucosal venous malformations	Alliance of Genome Resources
DOID:0050902	medulloblastoma	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0060230	basal ganglia calcification	Alliance of Genome Resources
DOID:0080109	infantile myofibromatosis	Alliance of Genome Resources
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:0111344	myeloproliferative disorder with eosinophilia	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 54 in total

1

2

3

4

5

6

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	5156	HGNC:8803
Homo sapiens	5159	HGNC:8804
Homo sapiens	7010	HGNC:11724
Homo sapiens	7075	HGNC:11809
Mus musculus	18596	MGI:97531
Mus musculus	21687	MGI:98664
Mus musculus	21846	MGI:99906
Rattus norvegicus	24629	RGD:3285
Danio rerio	30747	ZFIN:ZDB-GENE-990415-56
Rattus norvegicus	89804	RGD:620980

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements