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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
matrix metallopeptidase 3
Summary
- Gene Symbol
-
- MMP3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Collagen degradation
- Cytoplasm
- Direct protein sequencing
- Disulfide bond
- Extracellular matrix
- Innate immunity
- Metal-binding
- Metalloprotease
- Nucleus
- Reference proteome
- Repeat
- Signal
- Zinc
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| P08254 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cellular response to reactive oxygen species | ||
| proteolysis | ||
| regulation of cell migration | ||
| cellular response to UV-A | ||
| positive regulation of protein-containing complex assembly |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular matrix | ||
| extracellular region | ||
| mitochondrion | ||
| extracellular space | ||
| nucleus |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| zinc ion binding | ||
| metalloendopeptidase activity | ||
| endopeptidase activity | ||
| metallopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- metallopeptidase
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| collagen catabolic process |
| extracellular matrix organization |
| hydrolase activity |
| metal ion binding |
| metalloendopeptidase activity |
| metallopeptidase activity |
| proteolysis |
| zinc ion binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0060224 | atrial fibrillation | |
| DOID:0060903 | thrombosis | |
| DOID:0080855 | Parkinsonism | |
| DOID:0080933 | immunoglobulin light chain amyloidosis | |
| DOID:10808 | gastric ulcer | |
| DOID:10983 | Alport syndrome | |
| DOID:1222 | cartilage disease | |
| DOID:12236 | primary biliary cholangitis | |
| DOID:12894 | Sjogren's syndrome |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 17392 | MGI:97010 | MOUSE64515 | ||
| 171045 | RGD:621317 | RATNO40384 | ||
| 178748 | WB:WBGene00016283 | |||
| 281309 | BOVIN06330 | |||
| 396769 | PIGXX35281 | |||
| 397320 | PIGXX35281 | |||
| 403445 | CANLF15348 | |||
| 446898 | Xenbase:XB-GENE-5932566 | |||
| 451511 | 9598_0:00321d | PANTR04185 | ||
| 703762 | MACMU10444 |
