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Stromelysin-1

Summary

UniProt ID

P08254

Gene Symbol

MMP3
STMY1

Organism

Homo sapiens (human)

External Links

GlyGen: P08254
PubChem: P08254
The Human Metabolome Database: HMDBP02592

Annotation

Keyword

3D-structure
Calcium
Collagen degradation
Cytoplasm
Direct protein sequencing
Disulfide bond
Extracellular matrix
Innate immunity
Metal-binding
Metalloprotease
Nucleus
Reference proteome
Repeat
Signal
Zinc
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 17 in total

1

2

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GO Term
extracellular matrix disassembly
extracellular matrix organization
collagen catabolic process
positive regulation of protein-containing complex assembly
cellular response to reactive oxygen species
cellular response to amino acid stimulus
cellular response to nitric oxide
regulation of neuroinflammatory response
negative regulation of reactive oxygen species metabolic process
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying **all 6** entries
GO Term
extracellular region
extracellular space
nucleus
extracellular matrix
mitochondrion
cytosol

Displaying **all 6** entries
GO Term
peptidase activity
endopeptidase activity
serine-type endopeptidase activity
metalloendopeptidase activity
metallopeptidase activity
zinc ion binding

Annotation information from UniProt.

Sequence

MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
277			G43417UB	GlyGen
286			G43417UB	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Activation of Matrix Metalloproteinases	Homo sapiens
Assembly of collagen fibrils and other multimeric structures	Homo sapiens
Collagen degradation	Homo sapiens
Degradation of the extracellular matrix	Homo sapiens
EGFR Transactivation by Gastrin	Homo sapiens
Extra-nuclear estrogen signaling	Homo sapiens
Interleukin-4 and Interleukin-13 signaling	Homo sapiens