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Submissions

Toll

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

43222

PubChem

43222

Alliance of Genome Resources

FB:FBgn0262473

Annotation

Keyword

3D-structure
Cell adhesion
Cell membrane
Cytoplasm
Developmental protein
Disulfide bond
Glycoprotein
Innate immunity
Leucine-rich repeat
NAD
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P08953
T2GGK5
A0A0B4KHY4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 25 in total

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GO Term	Evidence Code	PMID
regulation of embryonic pattern specification	IMP	3931919
detection of virus	IDA	31088910
positive regulation of transcription by RNA polymerase II	IMP	25180232
signal transduction	IBA
Toll signaling pathway	IDA IGI IMP	10369678 10973475 12431377 12872120 15197269 24282309 31088910 34988396 36002459 3931918 7705656 8808632 8846922 9025065 9736738

GO Hierarchy

biological process

immune system process [inference]

immune response

innate immune response

antifungal innate immune response

cellular process [inference]

cell adhesion

signal transduction

cell surface receptor signaling pathway [inference]

Toll signaling pathway

cell competition in a multicellular organism

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

pattern specification process [inference]

axis specification [inference]

dorsal/ventral axis specification

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

muscle structure development [inference]

somatic muscle development [inference]

larval somatic muscle development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

synaptic target inhibition

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to oomycetes [inference]

defense response to oomycetes

response to virus [inference]

detection of virus

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to fungus [inference]

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to oomycetes

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response

antifungal innate immune response

defense response to fungus [inference]

antifungal innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to oomycetes

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response

antifungal innate immune response

defense response to fungus [inference]

antifungal innate immune response

response to wounding

immune response

innate immune response

antifungal innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to oomycetes [inference]

defense response to oomycetes

response to virus [inference]

detection of virus

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to fungus [inference]

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to oomycetes

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response

antifungal innate immune response

defense response to fungus [inference]

antifungal innate immune response

response to biotic stimulus [inference]

response to tumor cell

response to external biotic stimulus [inference]

response to other organism [inference]

response to oomycetes [inference]

defense response to oomycetes

response to virus [inference]

detection of virus

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to fungus [inference]

defense response to fungus [inference]

antifungal innate immune response

defense response to other organism [inference]

defense response to oomycetes

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response

antifungal innate immune response

defense response to fungus [inference]

antifungal innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of hemocyte proliferation

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of hemocyte proliferation [inference]

positive regulation of hemocyte proliferation

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

cell competition in a multicellular organism

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of hemocyte proliferation

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of hemocyte proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell growth

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of defense response to fungus [inference]

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of defense response to fungus [inference]

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of defense response to fungus [inference]

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of developmental process [inference]

regulation of hemocyte proliferation [inference]

positive regulation of hemocyte proliferation

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

Toll signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

regulation of antifungal peptide production [inference]

positive regulation of antifungal peptide production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of hemocyte proliferation

regulation of hemocyte proliferation [inference]

positive regulation of hemocyte proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of hemocyte proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of antifungal peptide production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell growth

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of hemocyte proliferation [inference]

positive regulation of hemocyte proliferation

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of embryonic pattern specification

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GO Term	Evidence Code	PMID
external side of plasma membrane	IDA	22464169
membrane	IEA
early endosome	IDA	20921412
plasma membrane	HDA IBA IDA	1879347 19154721 19317464 20404143 31088910 7635064
cell surface	IDA	1879347

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

cleavage furrow

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	11881810 16782008 18347020
TIR domain binding	IPI	11743586
cytokine receptor activity	IMP	12872120
NAD+ nucleotidase, cyclic ADP-ribose generating
identical protein binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

NAD+ nucleosidase activity [inference]

NAD+ nucleotidase, cyclic ADP-ribose generating

binding [inference]

protein binding

protein domain specific binding [inference]

TIR domain binding

virion binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

cytokine receptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Toll

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
immune response
toll-like receptor signaling pathway

Displaying **all 5** entries
InterPro
Leucine-rich repeat domain superfamily
Leucine-rich repeat
Toll-like receptor
Toll/interleukin-1 receptor homology (TIR) domain superfamily
Toll/interleukin-1 receptor homology (TIR) domain

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
membrane	FB:FBrf0231198
early endosome	PMID:20921412
cleavage furrow	PMID:1879347
cell surface	PMID:1879347
plasma membrane	PMID:1879347 PMID:19154721 PMID:19317464 PMID:20404143 PMID:31088910 PMID:7635064
external side of plasma membrane	PMID:22464169

Disease

Disease Ontology

Displaying entries **41 - 50** of 85 in total

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DO ID	Disease Name	Source
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:1495	cystic echinococcosis	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1679	cystitis	Alliance of Genome Resources
DOID:1909	melanoma	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:2957	pulmonary tuberculosis	Alliance of Genome Resources
DOID:2987	familial mediterranean fever	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 52 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	7099	HGNC:11850
Homo sapiens	7100	HGNC:11851
Mus musculus	21897	MGI:1341295
Mus musculus	21898	MGI:96824
Mus musculus	21899	MGI:1341296
Mus musculus	24088	MGI:1346060
Rattus norvegicus	29260	RGD:3870
Danio rerio	402884	ZFIN:ZDB-GENE-040220-4
Danio rerio	403131	ZFIN:ZDB-GENE-040219-8
Xenopus tropicalis	448153	Xenbase:XB-GENE-983372

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements