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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
serpin family C member 1
Summary
- Gene Symbol
-
- SERPINC1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Heparin-binding
- Phosphoprotein
- Reference proteome
- Secreted
- Serine protease inhibitor
- Signal
- Thrombophilia
- Proteins
| UniProt | Protein Name |
|---|---|
| P01008 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of peptidase activity | ||
| regulation of blood coagulation | ||
| blood coagulation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| collagen-containing extracellular matrix | ||
| endoplasmic reticulum lumen | ||
| plasma membrane | ||
| extracellular region | ||
| blood microparticle |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| heparin binding | ||
| serine-type endopeptidase inhibitor activity | ||
| protease binding | ||
| identical protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Serine Protease inhibitor
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| serine-type endopeptidase inhibitor activity |
| InterPro |
|---|
| Serpin domain |
| Serpin family |
| Serpin superfamily, domain 1 |
| Serpin superfamily, domain 2 |
| Serpin superfamily |
| Serpin, conserved site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060903 | thrombosis | |
| DOID:10159 | osteonecrosis | |
| DOID:11247 | disseminated intravascular coagulation | |
| DOID:1168 | familial hyperlipidemia | |
| DOID:1184 | nephrotic syndrome | |
| DOID:13372 | alpha 1-antitrypsin deficiency | |
| DOID:14115 | toxic shock syndrome | |
| DOID:2394 | ovarian cancer | |
| DOID:3021 | acute kidney failure | |
| DOID:3755 | antithrombin III deficiency |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 101052447 | SAIBB09159 | |||
| 101067648 | TAKRU27813 | |||
| 101093983 | FELCA37034 | |||
| 101146332 | 9595_0:000494 | |||
| 101170996 | ORYLA13420 | |||
| 101320848 | TURTR13806 | |||
| 101605325 | JACJA10272 | |||
| 101722222 | HETGA05743 | |||
| 101790898 | ANAPL07203 | |||
| 101809337 | FICAL04213 |
