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aconitase 1

Summary

Gene Symbol

ACO1

Aliases

IREBP
IRP1
aconitate hydratase, cytoplasmic
cytosplasmic aconitase
soluble aconitase

Organism

Homo sapiens (human)

External Links

NCBI Gene

HGNC

117

KEGG Gene ID

hsa:48

PubChem

Alliance of Genome Resources

HGNC:117

Annotation

Keyword

3D-structure
4Fe-4S
Cytoplasm
Direct protein sequencing
Lyase
Phosphoprotein
RNA-binding
Reference proteome
Tricarboxylic acid cycle

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P21399	Citrate hydro-lyase Ferritin repressor protein Iron regulatory protein 1 Iron-responsive element-binding protein 1
V9HWB7	Citrate hydro-lyase Iron-responsive element-binding protein 1
Q9HBB2	Citrate hydro-lyase Iron-responsive element-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of translation	IEA
citrate metabolic process	IBA IDA IMP	1281544 16527810 8041788
intracellular iron ion homeostasis	IEA
intestinal absorption	IEA
post-embryonic development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

citrate metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

citrate metabolic process

primary metabolic process [inference]

tricarboxylic acid cycle

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

citrate metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

citrate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

citrate metabolic process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption

post-embryonic development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to iron ion [inference]

response to iron(II) ion

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	16144863
cytosol	IBA IDA TAS	1281544 16527810
cytoplasm	IMP NAS	1281544 1738601
Golgi apparatus	IDA	16144863
mitochondrion	IBA IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
4 iron, 4 sulfur cluster binding	IBA IDA IMP	1281544 16407072
3 iron, 4 sulfur cluster binding	IBA IMP	1281544
aconitate hydratase activity	IBA IDA IMP	1281544 1946430 8041788
metal ion binding	IEA
iron-responsive element binding	IBA IDA IMP	1281544 23891004 8041788

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

aconitate hydratase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding [inference]

iron-responsive element binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000122729

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:10336

citrate

D-threo-isocitrate

Enzyme

4.2.1.3

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0111029	hemochromatosis type 1	DisGeNET
DOID:10021	duodenum cancer	DisGeNET
DOID:10041	dysplastic nevus syndrome	DisGeNET
DOID:10154	small intestine cancer	DisGeNET
DOID:10283	prostate cancer	DisGeNET
DOID:10286	prostate carcinoma	DisGeNET
DOID:10652	Alzheimer's disease	DisGeNET
DOID:10763	hypertension	DisGeNET
DOID:10825	essential hypertension	DisGeNET
DOID:10871	age related macular degeneration	DisGeNET

Ortholog

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Species	Gene ID	Orthologous MAtrix
Chrysemys picta bellii	101952327	CHRPI07906
Crocodylus porosus	109323487	CROPO13119
Pseudonaja textilis	113444623	PSETE17330
Serinus canaria	103821209	SERCA17220
Ornithorhynchus anatinus	100076717	ORNAN32215
Sarcophilus harrisii	100919050	SARHA16381
Callithrix jacchus	100415290	CALJA18548
Cercocebus atys	105590098	CERAT14107
Macaca fascicularis	102142663	MACFA11865
Macaca mulatta	705075	MACMU11728

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GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements