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phospholipase C gamma 2
Summary
- Gene Symbol
-
- PLCG2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Disease variant
- Hydrolase
- Lipid degradation
- Membrane
- Phosphoprotein
- Reference proteome
- Repeat
- SH2 domain
- SH3 domain
- Transducer
- Proteins
| UniProt | Protein Name |
|---|---|
| P16885 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of I-kappaB phosphorylation | ||
| cellular response to calcium ion | ||
| B cell differentiation | ||
| positive regulation of MAPK cascade | ||
| negative regulation of programmed cell death |
GO Hierarchy
- positive regulation of reactive oxygen species biosynthetic process
- positive regulation of reactive oxygen species biosynthetic process
- positive regulation of reactive oxygen species biosynthetic process
biological process
immune system process [inference]
metabolic process [inference]
cellular process [inference]
multicellular organismal process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of protein metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of response to stimulus [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| perinuclear region of cytoplasm | ||
| membrane raft | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phospholipase C activity |
|
|
| scaffold protein binding | ||
| protein kinase binding | ||
| protein tyrosine kinase binding | ||
| phosphotyrosine residue binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110047 | Alzheimer's disease 14 | |
| DOID:0110048 | Alzheimer's disease 15 | |
| DOID:0110892 | inflammatory bowel disease 1 | |
| DOID:10223 | dermatomyositis | |
| DOID:1040 | chronic lymphocytic leukemia | |
| DOID:10534 | stomach cancer | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10871 | age related macular degeneration | |
| DOID:10966 | lipoid nephrosis | |
| DOID:11476 | osteoporosis |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000403 | Recurrent otitis media |
| HP:0000518 | Cataract |
| HP:0000872 | Hashimoto thyroiditis |
| HP:0000989 | Pruritus |
| HP:0001045 | Vitiligo |
| HP:0002099 | Asthma |
| HP:0002720 | Decreased circulating IgA level |
| HP:0002829 | Arthralgia |
| HP:0002850 | Decreased circulating total IgM |
| Disease ID | Disease Name |
|---|---|
| OMIM:614878 |
|
| OMIM:614468 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000965
- Gene Name
- phospholipase C, gamma 2 (phosphatidylinositol-specific)
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100518663 | PIGXX27019 | ||
| 100337091 | BOVIN10207 | ||
| 102180337 | CAPHI08268 | ||
| 101122126 | SHEEP04893 | ||
| 100340139 | RABIT11105 | ||
| 100752475 | CRIGR00323 | ||
| 234779 | MGI:97616 | MOUSE58653 | |
| 29337 | RGD:3348 | RATNO14514 | |
| 100726796 | CAVPO24060 | ||
| 101587236 | OCTDE03389 |
