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cathepsin A

Summary

Gene Symbol

CTSA

Aliases

carboxypeptidase C
carboxypeptidase Y-like kininase
carboxypeptidase-L
deamidase
lysosomal carboxypeptidase A
lysosomal protective protein
urinary kininase

Organism

Homo sapiens (human)

External Links

NCBI Gene

5476

HGNC

9251

KEGG Gene ID

hsa:5476

PubChem

5476

Alliance of Genome Resources

HGNC:9251

Annotation

Keyword

3D-structure
Alternative splicing
Carboxypeptidase
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Signal
Zymogen

Proteins

Displaying **all 4** entries
UniProt	Protein Name
X6R8A1
P10619	Carboxypeptidase C Carboxypeptidase L Cathepsin A Protective protein cathepsin A Protective protein for beta-galactosidase
X6R5C5
B4E324

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
regulation of chaperone-mediated autophagy		20176123
proteolysis	IDA	12505983
negative regulation of chaperone-mediated autophagy	IGI	12505983
intracellular protein transport		1387645
regulation of protein stability	IMP	12505983

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

regulation of chaperone-mediated autophagy

negative regulation of chaperone-mediated autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of chaperone-mediated autophagy

negative regulation of chaperone-mediated autophagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

regulation of chaperone-mediated autophagy

negative regulation of chaperone-mediated autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of chaperone-mediated autophagy

negative regulation of chaperone-mediated autophagy

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of chaperone-mediated autophagy

negative regulation of chaperone-mediated autophagy

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

regulation of chaperone-mediated autophagy

negative regulation of chaperone-mediated autophagy

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

regulation of chaperone-mediated autophagy

negative regulation of chaperone-mediated autophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of chaperone-mediated autophagy

regulation of biological quality [inference]

regulation of protein stability

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
endoplasmic reticulum		1387645
extracellular region
membrane	HDA	19946888
lumenal side of lysosomal membrane		20176123

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of lysosomal membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type carboxypeptidase activity	IBA IMP	12505983 1907282
carboxypeptidase activity		2244901
enzyme activator activity		3107551

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

serine-type carboxypeptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

serine-type carboxypeptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000064601

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K13289

Name

cathepsin A (carboxypeptidase C) [EC:3.4.16.5]

References

Disease

Disease Ontology

Displaying entries **11 - 20** of 79 in total

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DO ID	Disease Name	Source
DOID:0080540	galactosialidosis	Glyco-Disease Genes Database DisGeNET Alliance of Genome Resources
DOID:0111035	CADASIL 1	DisGeNET
DOID:0111390	mucopolysaccharidosis Ih	DisGeNET
DOID:0111392	mucopolysaccharidosis type IVB	DisGeNET
DOID:10003	sensorineural hearing loss	DisGeNET
DOID:1003	pelvic inflammatory disease	DisGeNET
DOID:1059	intellectual disability	DisGeNET
DOID:1074	kidney failure	DisGeNET
DOID:10763	hypertension	DisGeNET
DOID:10825	essential hypertension	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 19 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000280	Coarse facial features
HP:0000365	Hearing impairment
HP:0000524	Conjunctival telangiectasia
HP:0000925	Abnormality of the vertebral column
HP:0000943	Dysostosis multiplex
HP:0001028	Hemangioma
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001433	Hepatosplenomegaly

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:256540	galactosialidosis
ORPHA:351	galactosialidosis

PubChem Disease

GHR Health Conditions

Galactosialidosis

MedGen Diseases

Combined deficiency of sialidase AND beta galactosidase

OMIM Phenotypes

GALACTOSIALIDOSIS; GSL

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	173818	WB:WBGene00018271
Caenorhabditis elegans	174057	WB:WBGene00019605
Caenorhabditis elegans	174189	WB:WBGene00017969
Caenorhabditis elegans	174802	WB:WBGene00008741
Caenorhabditis elegans	175938	WB:WBGene00021503
Caenorhabditis elegans	182429	WB:WBGene00007462
Petromyzon marinus	116944296		PETMA05198
Callorhinchus milii	103191463		CALMI05189
Latimeria chalumnae	102354641		LATCH19884
Danio rerio	321818	ZFIN:ZDB-GENE-030131-537	DANRE38179

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements