mitogen-activated protein kinase kinase 6

Summary
Gene Symbol
  • MAP2K6
Organism
Homo sapiens (human)
NCBI Gene
5608
PubChem
5608
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Alternative splicing
  • Apoptosis
  • Cytoskeleton
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Serine/threonine-protein kinase
  • Stress response
  • Transcription regulation
  • Tyrosine-protein kinase
Proteins
Displaying all 2 entries
UniProt Protein Name
P52564
  • MAPK/ERK kinase 6
  • Stress-activated protein kinase kinase 3
A8K3Y2
Gene Ontology (GO)
Displaying entries 1 - 5 of 26 in total
GO Term Evidence Code PMID
MAPK cascade
MAPK cascade
osteoblast differentiation
response to ischemia
apoptotic process
GO Hierarchy
Displaying entries 11 - 13 of 13 in total
GO Term Evidence Code PMID
identical protein binding
protein serine kinase activity
histone H2AXY142 kinase activity
GO Hierarchy
OrthoDB (Group)
Group level
Eukaryota
Group Name
dual specificity mitogen-activated
Functional Category
  • E: Amino acid transport and metabolism
  • Q: Secondary metabolites biosynthesis, transport and catabolism
  • T: Signal transduction mechanisms
Disease
Disease Ontology
Displaying all 5 entries
DO ID Disease Name Source
DOID:11870 Pick's disease
DOID:397 restrictive cardiomyopathy
DOID:4001 ovarian carcinoma
DOID:4362 cervical cancer
DOID:678 progressive supranuclear palsy

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025