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mitochondrial fission factor

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

56947

PubChem

56947

Alliance of Genome Resources

HGNC:24858

Annotation

Keyword

Alternative splicing
Coiled coil
Cytoplasmic vesicle
Mitochondrion outer membrane
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome
Synapse
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A9L9PY92
A0A0A0MS29
Q9GZY8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrial fission	IDA IMP ISS	18353969 21149567 23283981 23530241
peroxisome fission	IMP	18353969 21149567
mitochondrion organization	IMP	21149567
positive regulation of mitochondrial fission	IBA
protein targeting to mitochondrion	IBA IDA IMP ISS	21149567 23283981

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

mitochondrial fission

organelle fission [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

positive regulation of developmental process [inference]

positive regulation of mitochondrial fission

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fission [inference]

positive regulation of mitochondrial fission

positive regulation of developmental process [inference]

positive regulation of mitochondrial fission

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of mitochondrion organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of mitochondrial fission [inference]

positive regulation of mitochondrial fission

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

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GO Term	Evidence Code	PMID
mitochondrial membrane	IDA	18353969
peroxisome	IBA IDA	18353969 23921378
protein-containing complex	IDA	18353969
mitochondrial outer membrane	IBA IDA	21149567
mitochondrion	HTP IDA	34800366

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21149567 26358295 29464060 32296183 36217029
identical protein binding	IPI	18353969 32296183
protein homodimerization activity	IDA	23530241

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mitochondrial fission factor

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
mitochondrial fission
positive regulation of mitochondrial fission
positive regulation of protein targeting to membrane

Displaying **all 2** entries
InterPro
Mff-like domain
Mff/Tango-11

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:936	brain disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	75734		MGI:1922984	MOUSE27573
Drosophila melanogaster	246596		FB:FBgn0050404
Rattus norvegicus	301563		RGD:1310230	RATNO43097
Danio rerio	393508		ZFIN:ZDB-GENE-040426-1510
Xenopus laevis	443869		Xenbase:XB-GENE-5870309
Xenopus laevis	446760		Xenbase:XB-GENE-6255354
Pan troglodytes	459989	9598_0:000e6a		PANTR29922
Bos taurus	506291			BOVIN24855
Danio rerio	553588		ZFIN:ZDB-GENE-050522-208
Macaca mulatta	708489			MACMU06384