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prostaglandin I2 synthase
Summary
- Gene Symbol
-
- PTGIS
- Aliases
-
- CYP8A1
- PGIS
- cytochrome P450, family 8, subfamily A, polypeptide 1
- prostacyclin synthase
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Endoplasmic reticulum
- Heme
- Isomerase
- Lyase
- Prostaglandin biosynthesis
- Reference proteome
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q16647 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of NF-kappaB transcription factor activity | ||
| cellular response to interleukin-1 | ||
| cyclooxygenase pathway |
|
|
| cellular response to interleukin-6 | ||
| positive regulation of execution phase of apoptosis |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
organic acid metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organic acid metabolic process [inference]
lipid metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
cellular process [inference]
cellular metabolic process [inference]
organic acid metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| endoplasmic reticulum | ||
| extracellular space | ||
| caveola | ||
| endoplasmic reticulum membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| heme binding | ||
| prostaglandin-I synthase activity | ||
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | ||
| iron ion binding | ||
| hydroperoxy icosatetraenoate dehydratase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- cytochrome P450
- Functional Category
-
- I: Lipid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| heme binding |
| iron ion binding |
| metal ion binding |
| monooxygenase activity |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| InterPro |
|---|
| Cytochrome P450 superfamily |
| Cytochrome P450 |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050852 | limb ischemia | |
| DOID:0050860 | colorectal adenoma | |
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0080491 | cerebral cavernous malformation 1 | |
| DOID:10763 | hypertension | |
| DOID:10825 | essential hypertension | |
| DOID:13001 | carotid stenosis | |
| DOID:13832 | patent ductus arteriosus | |
| DOID:14330 | Parkinson's disease | |
| DOID:14557 | primary pulmonary hypertension |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001426 | Non-Mendelian inheritance |
| HP:0004421 | Elevated systolic blood pressure |
| HP:0004972 | Elevated mean arterial pressure |
| HP:0005117 | Elevated diastolic blood pressure |
| Disease ID | Disease Name |
|---|---|
| OMIM:145500 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000894
- Gene Name
- prostaglandin I2 (prostacyclin) synthase
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 19223 | MGI:1097156 | MOUSE34493 | ||
| 25527 | RGD:3438 | RATNO28060 | ||
| 458323 | 9598_0:00500e | PANTR25103 | ||
| 559148 | ZFIN:ZDB-GENE-070116-1 | |||
| 703407 | MACMU01137 | |||
| 100029131 | MONDO06219 | |||
| 100071412 | HORSE20773 | |||
| 100076102 | ORNAN25929 | |||
| 100076187 | ORNAN25929 | |||
| 100126284 | PIGXX11934 |
