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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
complement factor B
Summary
- Gene Symbol
-
- CFB
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Alternative splicing
- Cleavage on pair of basic residues
- Complement alternate pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycation
- Glycoprotein
- Hemolytic uremic syndrome
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sushi
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| P00751 |
|
| A0A1U9X7H8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| complement activation, alternative pathway | ||
| response to bacterium | ||
| complement activation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| extracellular region | ||
| blood microparticle | ||
| extracellular space | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| complement binding | ||
| serine-type endopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Complement factor B
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Sushi/SCR/CCP domain |
| Sushi/SCR/CCP superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050127 | sinusitis | |
| DOID:0080162 | lupus nephritis | |
| DOID:0080301 | atypical hemolytic-uremic syndrome | |
| DOID:0080322 | polycystic kidney disease | |
| DOID:0080750 | erythema nodosum | |
| DOID:0110019 | age related macular degeneration 7 | |
| DOID:0110026 | age related macular degeneration 14 | |
| DOID:10887 | lepromatous leprosy | |
| DOID:10923 | sickle cell anemia | |
| DOID:10976 | membranous glomerulonephritis |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 14962 | MGI:105975 | MOUSE20425 | ||
| 24226 | RGD:2204 | |||
| 30489 | ZFIN:ZDB-GENE-990415-34 | |||
| 30604 | ZFIN:ZDB-GENE-980526-487 | |||
| 373577 | Xenbase:XB-GENE-865266 | |||
| 397725 | Xenbase:XB-GENE-17335705 | |||
| 494140 | 9598_0:001ed0 | |||
| 497244 | CIOIN03737 | |||
| 514076 | BOVIN18745 | |||
| 792472 | ZFIN:ZDB-GENE-030131-2319 |
