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MIRAGE
Complement factor B

Summary
UniProt ID
P00751
Gene Symbol
  • BF
  • BFD
  • CFB
Gene ID
629
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011283
GlyConnect
GlyGen
P00751
PubChem
P00751
RaftProt
P00751
Re-Glyco
P00751
Annotation
Keyword
  • 3D-structure
  • Age-related macular degeneration
  • Alternative splicing
  • Cleavage on pair of basic residues
  • Complement alternate pathway
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycation
  • Hemolytic uremic syndrome
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Sushi
  • Zymogen
Gene Ontology (GO)
Displaying all 5 entries
GO Term
extracellular region
extracellular space
plasma membrane
extracellular exosome
blood microparticle
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
serine-type endopeptidase activity
complement binding
Annotation information from UniProt.
Sequence
MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 7 entries
Position Description PubMed ID GlyTouCan ID Source
25
26
122 N-linked (GlcNAc...) asparagine
142 N-linked (GlcNAc...) asparagine
285 N-linked (GlcNAc...) asparagine
291 N-linked (Glc) (glycation) lysine
378 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
Activation of C3 and C5 Homo sapiens
Alternative complement activation Homo sapiens
Regulation of Complement cascade Homo sapiens
Disease
Displaying entries 1 - 10 of 12 in total
DO ID Disease Name Source
DOID:0080301 atypical hemolytic-uremic syndrome
DOID:0110026 age related macular degeneration 14
DOID:10923 sickle cell anemia
DOID:10976 membranous glomerulonephritis
DOID:1407 anterior uveitis
DOID:2920 membranoproliferative glomerulonephritis
DOID:2986 IgA glomerulonephritis
DOID:4448 macular degeneration
DOID:8893 psoriasis
DOID:8947 diabetic retinopathy
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025