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MIRAGE
C-C motif chemokine ligand 2
Summary
- Gene Symbol
-
- CCL2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Chemotaxis
- Cytokine
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Inflammatory response
- Pyrrolidone carboxylic acid
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P13500 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| sensory perception of pain | ||
| cellular homeostasis | ||
| positive regulation of cell migration | ||
| negative regulation of glial cell apoptotic process | ||
| helper T cell extravasation |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of transmembrane transport [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell cycle [inference]
regulation of cell motility [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| CCR2 chemokine receptor binding | ||
| chemoattractant activity | ||
| CCR chemokine receptor binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- C chemokine
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cell chemotaxis |
| chemokine activity |
| cytokine activity |
| eosinophil chemotaxis |
| immune response |
| InterPro |
|---|
| Chemokine beta/gamma/delta |
| Chemokine interleukin-8-like domain |
| Chemokine interleukin-8-like superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0080162 | lupus nephritis | |
| DOID:11123 | IgA vasculitis | |
| DOID:1168 | familial hyperlipidemia | |
| DOID:13207 | proliferative diabetic retinopathy | |
| DOID:13241 | Behcet's disease | |
| DOID:13375 | temporal arteritis | |
| DOID:1407 | anterior uveitis | |
| DOID:1474 | aggressive periodontitis | |
| DOID:1588 | thrombocytopenia |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 6347 | ZFIN:ZDB-GENE-140718-1 | ||
| 6352 | ZFIN:ZDB-GENE-081022-33 | ||
| 6354 | RGD:1309255 | ||
| 6356 | ZFIN:ZDB-GENE-140718-1 | ||
| 6358 | ZFIN:ZDB-GENE-140718-1 | ||
| 20292 | ZFIN:ZDB-GENE-081022-33 | ||
| 20296 | RGD:3645 | ||
| 24770 | RGD:3645 | ||
| 748205 | PANTR14294 | ||
| 100022317 | MONDO14789 |
