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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
bone morphogenetic protein 2
Summary
- Gene Symbol
-
- BMP2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Chondrogenesis
- Cleavage on pair of basic residues
- Cytokine
- Developmental protein
- Differentiation
- Disease variant
- Disulfide bond
- Dwarfism
- Glycoprotein
- Growth factor
- Osteogenesis
- Pharmaceutical
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cell population proliferation | ||
| heart induction | ||
| cardiac atrium formation | ||
| cardiac jelly development | ||
| cardiac muscle tissue morphogenesis |
GO Hierarchy
- positive regulation of cartilage development
- positive regulation of cartilage development
biological process
metabolic process [inference]
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of hormone biosynthetic process [inference]
regulation of lipid biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of hormone biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of hormone metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of lipid metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
negative regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
positive regulation of cell differentiation [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of signaling [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of response to stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
positive regulation of cell differentiation [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
negative regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of hormone biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
regulation of biological quality [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| intracellular membrane-bounded organelle | ||
| plasma membrane |
|
|
| BMP receptor complex | ||
| extracellular region | ||
| cell surface |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| co-receptor binding | ||
| protein binding | ||
| signaling receptor binding | ||
| BMP receptor binding | ||
| cytokine activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Bone morphogenetic protein
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine activity |
| growth factor activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050591 | tooth agenesis | |
| DOID:0050787 | juvenile polyposis syndrome | |
| DOID:0110965 | brachydactyly type A2 | |
| DOID:0111029 | hemochromatosis type 1 | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:10763 | hypertension | |
| DOID:11476 | osteoporosis | |
| DOID:12185 | otosclerosis | |
| DOID:14323 | Marfan syndrome |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 12156 | MGI:88177 | MOUSE35213 | ||
| 29373 | RGD:2211 | RATNO26704 | ||
| 30631 | ZFIN:ZDB-GENE-980526-388 | |||
| 30632 | ZFIN:ZDB-GENE-980526-474 | |||
| 33432 | FB:FBgn0000490 | |||
| 179068 | WB:WBGene00000936 | |||
| 378780 | Xenbase:XB-GENE-481833 | |||
| 397873 | Xenbase:XB-GENE-6252323 | |||
| 458090 | 9598_0:0050d4 | PANTR24337 | ||
| 477162 | CANLF09307 |
