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MIRAGE
Bone morphogenetic protein 2
Summary
- UniProt ID
- P12643
- Gene Symbol
-
- BMP2
- BMP2A
- Gene ID
- 650
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011505
- GlyGen
- P12643
- PubChem
- P12643
- The Human Metabolome Database
- HMDBP02308
- Re-Glyco
- P12643
Annotation
- Keyword
-
- 3D-structure
- Chondrogenesis
- Cleavage on pair of basic residues
- Cytokine
- Developmental protein
- Differentiation
- Disease variant
- Disulfide bond
- Dwarfism
- Glycoprotein
- Growth factor
- Osteogenesis
- Pharmaceutical
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| intracellular membrane-bounded organelle |
| cell surface |
| BMP receptor complex |
Sequence
MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 86 |
|
|||
| 135 | N-linked (GlcNAc...) asparagine |
|
||
| 163 | N-linked (GlcNAc...) asparagine | |||
| 164 | N-linked (GlcNAc...) asparagine | |||
| 200 | N-linked (GlcNAc...) asparagine |
|
||
| 210 |
|
|
||
| 338 | N-linked (GlcNAc...) (high mannose) asparagine |
|
G57321FI
G80920RR
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Molecules associated with elastic fibres | Homo sapiens |
| Regulation of RUNX2 expression and activity | Homo sapiens |
| Signaling by BMP | Homo sapiens |
| Transcriptional regulation by RUNX2 | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050591 | tooth agenesis | |
| DOID:0060989 | short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1 | |
| DOID:0110965 | brachydactyly type A2 | |
| DOID:0111029 | hemochromatosis type 1 | |
| DOID:10283 | prostate cancer | |
| DOID:11476 | osteoporosis | |
| DOID:12185 | otosclerosis | |
| DOID:8398 | osteoarthritis |
