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MIRAGE
bone morphogenetic protein 4
Summary
- Gene Symbol
-
- BMP4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Chondrogenesis
- Cleavage on pair of basic residues
- Cytokine
- Developmental protein
- Differentiation
- Disease variant
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Growth factor
- Microphthalmia
- Osteogenesis
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of primary miRNA processing | ||
| negative regulation of extrinsic apoptotic signaling pathway |
GO Hierarchy
- regulation of cell fate commitment
- regulation of mesodermal cell differentiation
- regulation of cell fate commitment
- regulation of mesodermal cell differentiation
biological process
metabolic process [inference]
cellular process [inference]
multicellular organismal process [inference]
developmental process [inference]
anatomical structure morphogenesis [inference]
anatomical structure development [inference]
cellular developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of developmental process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of anatomical structure morphogenesis [inference]
regulation of cell differentiation [inference]
regulation of epithelial cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
negative regulation of developmental process [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
regulation of epithelial cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytokine activity | ||
| cytokine activity | ||
| protein binding | ||
| growth factor activity | ||
| heparin binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- bone morphogenetic protein
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine activity |
| growth factor activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050591 | tooth agenesis | |
| DOID:0060887 | ossification of the posterior longitudinal ligament of spine | |
| DOID:0080205 | CAKUT | |
| DOID:0080207 | CAKUT2 | |
| DOID:0080404 | orofacial cleft 11 | |
| DOID:0111805 | syndromic microphthalmia 6 | |
| DOID:12185 | otosclerosis | |
| DOID:1222 | cartilage disease | |
| DOID:1882 | atrial heart septal defect | |
| DOID:1909 | melanoma |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 110199877 | PHACI33885 | ||
| 112921419 | VULVU14241 | ||
| 113435122 | PSETE05883 | ||
| 113572633 | ELEEL13300 | ||
| 113900398 | BOBOX23194 | ||
| 114042421 | VOMUR29698 | ||
| 114594877 | PODMU07127 | ||
| 115035831 | ECHNA41039 | ||
| 115162164 | SALTR56982 | ||
| 115172445 | SALTR72890 |
