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steroid 5 alpha-reductase 2
Summary
- Gene Symbol
-
- SRD5A2
- Aliases
-
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Disease variant
- Lipid metabolism
- Microsome
- NADP
- Oxidoreductase
- Pseudohermaphroditism
- Reference proteome
- Sexual differentiation
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P31213 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| hippocampus development | ||
| response to xenobiotic stimulus | ||
| phthalate metabolic process | ||
| steroid catabolic process | ||
| female genitalia development |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| neuronal cell body | ||
| endoplasmic reticulum membrane |
|
|
| cell body fiber |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| amide binding | ||
| testosterone dehydrogenase [NAD(P)] activity | ||
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity | ||
| protein binding | ||
| 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) |
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1837 | diabetic ketoacidosis | |
| DOID:1883 | hepatitis C | |
| DOID:0050457 | Sertoli cell-only syndrome | |
| DOID:0050741 | alcohol dependence | |
| DOID:0050801 | androgenic alopecia | |
| DOID:0050830 | peripheral artery disease | |
| DOID:0060262 | gallbladder disease | |
| DOID:0070186 | Y-linked spermatogenic failure 1 | |
| DOID:0080144 | childhood acute lymphocytic leukemia | |
| DOID:0090091 | hypogonadotropic hypogonadism 23 with or without anosmia |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000028 | Cryptorchidism |
| HP:0000033 | Ambiguous genitalia, male |
| HP:0000046 | Small scrotum |
| HP:0000048 | Bifid scrotum |
| HP:0000051 | Perineal hypospadias |
| HP:0000054 | Micropenis |
| HP:0000062 | Ambiguous genitalia |
| HP:0000144 | Decreased fertility |
| HP:0000818 | Abnormality of the endocrine system |
| Disease ID | Disease Name |
|---|---|
| ORPHA:753 |
|
| OMIM:264600 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP002521
- Gene Name
- steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100454013 | PONAB23668 | ||
| 403715 | CANLF05022 | ||
| 112932999 | VULVU28850 | ||
| 123799861 | URSAM06602 | ||
| 100466687 | AILME04757 | ||
| 101683373 | MUSPF02487 | ||
| 101086898 | FELCA05996 | ||
| 122215122 | PANLE02263 | ||
| 100070655 | HORSE09564 | ||
| 397048 | PIGXX22302 |
