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kallikrein related-peptidase 5

Summary

Gene Symbol

Klk5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

68668

PubChem

68668

Alliance of Genome Resources

MGI:1915918

Annotation

Keyword

Disulfide bond
Proteomics identification
Reference proteome
Serine protease
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9D140

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
positive regulation of antibacterial peptide production	ISO
proteolysis
extracellular matrix disassembly	IBA
positive regulation of G protein-coupled receptor signaling pathway	ISO
protein maturation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth [inference]

amelogenesis

anatomical structure formation involved in morphogenesis [inference]

amelogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region
extracellular space	ISO
extracellular space	IBA
secretory granule	IBA
epidermal lamellar body	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

lamellar body [inference]

epidermal lamellar body

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

lamellar body [inference]

epidermal lamellar body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

lamellar body [inference]

epidermal lamellar body

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IBA
peptidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Serine proteases, trypsin family, serine active site

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	354	FB:FBgn0052808
Drosophila melanogaster	3816	FB:FBgn0052808
Drosophila melanogaster	3817	FB:FBgn0052808
Drosophila melanogaster	5653	FB:FBgn0052808
Drosophila melanogaster	11012	FB:FBgn0052808
Drosophila melanogaster	11202	FB:FBgn0052808
Drosophila melanogaster	13646	FB:FBgn0052808
Drosophila melanogaster	13647	FB:FBgn0052808
Drosophila melanogaster	13648	FB:FBgn0052808
Drosophila melanogaster	16612	FB:FBgn0052808

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OrthoDB (Group)

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Acknowledgements