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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
tissue factor pathway inhibitor
Summary
- Gene Symbol
-
- TFPI
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Blood coagulation
- Direct protein sequencing
- Disulfide bond
- GPI-anchor
- Microsome
- Reference proteome
- Repeat
- Secreted
- Serine protease inhibitor
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P10646 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of peptidase activity | ||
| negative regulation of blood coagulation | ||
| cellular response to steroid hormone stimulus | ||
| blood coagulation |
GO Hierarchy
biological process
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| side of membrane | ||
| extracellular region | ||
| cell surface | ||
| endoplasmic reticulum |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| endopeptidase inhibitor activity | ||
| serine-type endopeptidase inhibitor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Kunitz-type serine protease inhibitor
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| peptidase inhibitor activity |
| serine-type endopeptidase inhibitor activity |
| InterPro |
|---|
| Pancreatic trypsin inhibitor Kunitz domain superfamily |
| Pancreatic trypsin inhibitor Kunitz domain |
| Proteinase inhibitor I2, Kunitz, conserved site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0060224 | atrial fibrillation | |
| DOID:0080630 | B-lymphoblastic leukemia/lymphoma | |
| DOID:0081267 | graft-versus-host disease | |
| DOID:0111144 | preterm premature rupture of the membranes | |
| DOID:10159 | osteonecrosis | |
| DOID:10591 | pre-eclampsia | |
| DOID:10772 | thrombotic thrombocytopenic purpura | |
| DOID:11247 | disseminated intravascular coagulation | |
| DOID:1168 | familial hyperlipidemia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 21788 | MGI:1095418 | MOUSE34099 | ||
| 29436 | RGD:61914 | RATNO26214 | ||
| 35896 | FB:FBgn0033355 | |||
| 179593 | WB:WBGene00009386 | |||
| 326147 | FB:FBgn0051515 | |||
| 359833 | ZFIN:ZDB-GENE-030711-1 | DANRE44989 | ||
| 403921 | CANLF14041 | |||
| 470603 | 9598_0:000d1a | PANTR29340 | ||
| 508763 | BOVIN23916 | |||
| 613026 | MACMU06487 |
