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aladin WD repeat nucleoporin

Summary

Gene Symbol

AAAS

Organism

Homo sapiens (human)

External Links

NCBI Gene

8086

PubChem

8086

Alliance of Genome Resources

HGNC:13666

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoskeleton
Disease variant
Nuclear pore complex
Phosphoprotein
Reference proteome
Repeat
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NRG9	Adracalin

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
microtubule bundle formation	IMP	26246606
glutathione metabolic process	IEA
nucleocytoplasmic transport	NAS	27016207
nucleocytoplasmic transport	IDA	12730363
nucleocytoplasmic transport	IBA

GO Hierarchy

biological process

metabolic process [inference]

organic substance metabolic process [inference]

glutathione metabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

cell cycle process [inference]

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

spindle organization [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

spindle assembly [inference]

mitotic spindle assembly

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization [inference]

mitotic spindle assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

reproductive process [inference]

fertilization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

multicellular organism growth

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport

organic substance transport [inference]

protein transport

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

mRNA transport

nitrogen compound transport [inference]

protein transport

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

mRNA transport

establishment of protein localization [inference]

protein transport

establishment of RNA localization [inference]

RNA transport [inference]

mRNA transport

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport

regulation of cellular process [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport

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GO Term	Evidence Code	PMID
spindle pole	IDA	26246606
nucleus	HDA	21630459
nuclear envelope	TAS
nuclear envelope	IDA	24315095 27754849
nuclear pore	NAS	24315095

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear pore

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

membrane

organelle membrane [inference]

nuclear membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	27754849

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aladin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Aladin
WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050602	triple-A syndrome	Alliance of Genome Resources
DOID:9164	achalasia	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8086	Xenbase:XB-GENE-967146
Mus musculus	223921		MOUSE16894
Rattus norvegicus	300259		RATNO38823
Danio rerio	378454		DANRE45500
Pan troglodytes	467003		PANTR05739
Bos taurus	506561		BOVIN29070
Canis lupus familiaris	607867		CANLF10736
Macaca mulatta	719095		MACMU05370
Equus caballus	100063811		HORSE37245
Sus scrofa	100154333		PIGXX25430

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements