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calpain 1

Summary

Gene Symbol

CAPN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

823

PubChem

823

Alliance of Genome Resources

HGNC:1476

Annotation

Keyword

3D-structure
Acetylation
Autocatalytic cleavage
Calcium
Cell membrane
Cytoplasm
Disease variant
Hereditary spastic paraplegia
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Thiol protease

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DWH5	Calcium-activated neutral proteinase 1 Calpain mu-type Calpain-1 large subunit Micromolar-calpain
B2RDI5	Calcium-activated neutral proteinase 1 Calpain mu-type Calpain-1 large subunit Micromolar-calpain
P07384	Calcium-activated neutral proteinase 1 Calpain mu-type Calpain-1 large subunit Cell proliferation-inducing gene 30 protein Micromolar-calpain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
proteolysis	ISS
proteolysis	NAS	16411745
proteolysis	IDA	16411745 21531719 2400579 2407243
proteolysis	IBA
positive regulation of cell population proliferation	TAS	8702541

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

self proteolysis

catabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

self proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

protein metabolic process [inference]

proteolysis

self proteolysis

receptor metabolic process [inference]

receptor catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

self proteolysis

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

NMDA selective glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

NMDA selective glutamate receptor signaling pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

multicellular organismal process [inference]

tissue remodeling [inference]

mammary gland involution

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

NMDA selective glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

NMDA selective glutamate receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of molecular function [inference]

regulation of catalytic activity

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cornified envelope	IEA
extracellular region	TAS
cytoplasm	IBA
mitochondrion	IEA
lysosome	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

caspase complex [inference]

calpain complex

cellular anatomical entity [inference]

membrane

plasma membrane

cornified envelope

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
calcium-dependent cysteine-type endopeptidase activity	ISS
calcium-dependent cysteine-type endopeptidase activity	TAS	17526495
calcium-dependent cysteine-type endopeptidase activity	IDA	16411745 19617626 2407243
calcium-dependent cysteine-type endopeptidase activity	IBA
calcium ion binding	IDA	9271093

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

calcium-dependent cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

calcium-dependent cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

calcium-dependent cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

calcium-dependent cysteine-type endopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

calpain

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
calcium-dependent cysteine-type endopeptidase activity
hydrolase activity
proteolysis

Displaying **all 3** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C2, calpain family
Peptidase C2, calpain, catalytic domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110821	hereditary spastic paraplegia 76	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 50 in total

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Species	Gene ID	Orthologous MAtrix
Vulpes vulpes	112924271	VULVU17945
Pseudonaja textilis	113446716	PSETE19895
Vombatus ursinus	114038672	VOMUR24561
Podarcis muralis	114586334	PODMU27463
Strigops habroptila	115603498	STRHB06668
Corvus moneduloides	116437241	CORMO16916
Chelonoidis abingdonii	116838779	CHEAB03248
Rhinolophus ferrumequinum	117030631	RHIFE28998
Balaenoptera musculus	118899197	BALMU09559
Panthera leo	122199514	PANLE15070

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Acknowledgements