GlyCosmos Portal

Annotation

Keyword

Direct protein sequencing
Disease variant
FAD
Fatty acid metabolism
Oxidoreductase
Peroxisome
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99424	3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase Trihydroxycoprostanoyl-CoA oxidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
fatty acid beta-oxidation using acyl-CoA oxidase	IBA IDA IMP	27884763
very long-chain fatty acid metabolic process	IBA
bile acid biosynthetic process	IDA	27884763
lipid homeostasis	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process [inference]

bile acid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process [inference]

bile acid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process [inference]

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound metabolic process [inference]

bile acid metabolic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation [inference]

fatty acid beta-oxidation using acyl-CoA oxidase

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
cytosol	IDA TAS
peroxisome	IBA IDA IMP ISS	2079609 27884763 8943006
peroxisomal matrix

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
flavin adenine dinucleotide binding	IBA ISS
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity	IBA IDA ISS	27884763
protein homodimerization activity	ISS
fatty acid binding	IBA
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [inference]

acyl-CoA oxidase activity [inference]

palmitoyl-CoA oxidase activity

oxidoreductase activity, acting on CH or CH2 groups [inference]

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

fatty acid binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

fatty acid binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

FAD binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

fatty acid binding

flavin adenine dinucleotide binding

FAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000168306

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K10214

Name

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3]

References

Rhea

RHEA:15733

A + H₂O + (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oyl-CoA

AH₂ + (24R,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oyl-CoA

Enzyme

1.17.99.3

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0080476	peroxisome biogenesis disorder 1A	DisGeNET
DOID:0111067	congenital bile acid synthesis defect 6	DisGeNET Alliance of Genome Resources
DOID:10602	obsolete steatorrhea	DisGeNET
DOID:114	heart disease	DisGeNET
DOID:1287	cardiovascular system disease	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET DisGeNET
DOID:3459	breast carcinoma	DisGeNET DisGeNET
DOID:3571	liver cancer	DisGeNET
DOID:684	hepatocellular carcinoma	DisGeNET DisGeNET
DOID:687	hepatoblastoma	DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 12** of 12 in total

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HPO ID	HPO Term
HP:0003593	Infantile onset
HP:0100512	Decreased circulating vitamin D concentration

Displaying 1 entry
Disease ID	Disease Name
OMIM:617308	congenital bile acid synthesis defect 6

PubChem Disease

MedGen Diseases

Congenital bile acid synthesis defect 6

OMIM Phenotypes

BILE ACID SYNTHESIS DEFECT, CONGENITAL, 6; CBAS6

KEGG Diseases

Congenital bile acid synthesis defect

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000966
Gene Name: acyl-CoA oxidase 2, branched chain

Ortholog

Displaying entries **61 - 70** of 80 in total

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Species	Gene ID	Orthologous MAtrix
Ictidomys tridecemlineatus	101969528	ICTTR03608
Jaculus jaculus	101607493	JACJA20994
Myotis lucifugus	102428739	MYOLU13520
Rhinolophus ferrumequinum	117036966	RHIFE16116
Taeniopygia guttata	100228411	TAEGU03814
Ficedula albicollis	101820029	FICAL03976
Chlorocebus sabaeus	103227815	CHLSB10477
Rhinopithecus bieti	108543617	RHIBE05449
Rhinopithecus roxellana	104660198	RHIRO17490
Nomascus leucogenys	100579193	NOMLE29915

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements