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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

Summary

Gene Symbol

B3GNT5

Aliases

B3GN-T5
beta3Gn-T5
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

84002

GGDB ID

gg119

HGNC

15684

mRNA

NM_032047

map

3q28

Protein

NP_114436

OMIM

615333

KEGG Gene ID

hsa:84002

PubChem

84002

Alliance of Genome Resources

HGNC:15684

Annotation

Keyword

Developmental protein
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BYG0	Lactotriaosylceramide synthase UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
protein glycosylation	TAS	11384981

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

developmental process [inference]

anatomical structure development [inference]

system development [inference]

central nervous system development

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity	TAS
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	IBA IDA	11384981
protein binding	IPI	32296183
beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

beta-1,3-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg119

Gene Symbol

B3GNT5

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G84224TW	G06239NA	11283017

Displaying **all 5** entries
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G84224TW	G06239NA	11283017
UDP-GlcNAc	G00058MO	G73480MV	11283017
UDP-GlcNAc	G46055MA	G25181AD	11283017
UDP-GlcNAc	G58896AZ	G70874WW	11283017
UDP-GlcNAc	G60687RJ	G81934BB	11283017

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G65889KE		11283017

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_344041	XM_344041
Mus musculus	NP_473393	NM_054052

KEGG BRITE Database

Orthology

K03766

Name

beta-1,3-N-acetylglucosaminyltransferase 5 [EC:2.4.1.206]

References

11283017

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05971	2.4.1.206	G84224TW	G06239NA

Rhea

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + UDP-N-acetyl-α-D-glucosamine

H⁺ + a β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + UDP

Enzyme

2.4.1.206

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:1612	breast cancer	DisGeNET
DOID:3068	glioblastoma	DisGeNET
DOID:3074	giant cell glioblastoma	DisGeNET
DOID:3459	breast carcinoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000869
Gene Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

Ortholog

Displaying entries **51 - 60** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Capra hircus	102189161		CAPHI12221
Oryctolagus cuniculus	100352940		RABIT04666
Dipodomys ordii	105998376		DIPOR19941
Cricetulus griseus	100757919		CRIGR19761
Mus musculus	108105	MGI:2137302	MOUSE18473
Rattus norvegicus	116740	RGD:70955	RATNO03978
Cavia porcellus	100721740		CAVPO04565
Octodon degus	101578833		OCTDE19573
Heterocephalus glaber	101723270		HETGA00527
Melopsittacus undulatus	101878339		MELUD11012

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024