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Standards Ontologies Notations
paraoxonase 1

Summary
Gene Symbol
  • Pon1
Organism
Rattus norvegicus (Norway rat)
NCBI Gene
84024
PubChem
84024
Alliance of Genome Resources
Annotation
Keyword
  • Calcium
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • HDL
  • Hydrolase
  • Metal-binding
  • Reference proteome
  • Secreted
  • Signal
Proteins
Displaying 1 entry
UniProt Protein Name
P55159
  • Aromatic esterase 1
  • Serum aryldialkylphosphatase 1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 11 - 13 of 13 in total
GO Term Evidence Code PMID
lactone catabolic process
response to fatty acid
response to fluoride
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Rodentia
Group Name
serum paraoxonase/arylesterase 1
Functional Category
  • G: Carbohydrate transport and metabolism
  • P: Inorganic ion transport and metabolism
  • X: Mobilome: prophages, transposons
Displaying all 6 entries
Gene Ontology
acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
hydrolase activity
metal ion binding
response to toxic substance
Displaying all 3 entries
InterPro
Arylesterase
Paraoxonase1
Six-bladed beta-propeller, TolB-like
Alliance of Genome Resources
Expression
Displaying 1 entry
Location References
Rhea

RHEA:22576

H2O + an N-acyl-L-homoserine lactone
H+ + an N-acyl-L-homoserine
Enzyme
PMID

RHEA:18053

H2O + paraoxon
diethylphosphate + H+ + 4-nitrophenol
Enzyme
PMID

RHEA:17309

a phenyl acetate + H2O
H+ + acetate + a phenol
Enzyme
PMID
Disease
Disease Ontology
Displaying entries 1 - 10 of 49 in total
DO ID Disease Name Source
DOID:0050731 vitamin B12 deficiency
DOID:0060060 non-Hodgkin lymphoma
DOID:0060669 cerebral cavernous malformation
DOID:0080001 bone disease
DOID:0080771 beta-thalassemia major
DOID:10126 keratoconus
DOID:10283 prostate cancer
DOID:1040 chronic lymphocytic leukemia
DOID:10603 glucose intolerance
DOID:10608 celiac disease
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP012808
Gene Name
paraoxonase 1
Ortholog
Displaying entries 21 - 30 of 50 in total
Species Gene ID OrthoDB Alliance of Genome Resources Orthologous MAtrix
104847857 885580_0:00054c
106000583 10020_0:004795
107144451 9994_0:003539
109693468 51338_0:002d7b
110296505 10089_0:0018a7
110316677 10093_0:000bdf
110559638 10047_0:003401
113184743 9999_0:0016c4
114107955 93162_0:003f6e
114630828 491861_0:002820
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024