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beta-1,4-galactosyltransferase 2

Summary

Gene Symbol

B4GALT2

Aliases

Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
N-acetyllactosamine synthase
beta4Gal-T2
lactose synthase A

Organism

Homo sapiens (human)

External Links

NCBI Gene

8704

GGDB ID

gg078

HGNC

925

mRNA

NM_003780

map

1p34-p33

Protein

NP_003771

OMIM

604013

KEGG Gene ID

hsa:8704

PubChem

8704

Alliance of Genome Resources

HGNC:925

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O60909	Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Lactose synthase A protein N-acetyllactosamine synthase Nal synthase UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
visual learning	IEA
carbohydrate metabolic process	IEA
locomotory behavior	IEA
memory	IEA
cerebellar Purkinje cell layer development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

locomotory behavior

visual behavior [inference]

visual learning

developmental process [inference]

anatomical structure development [inference]

cerebellar Purkinje cell layer development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

Displaying **all 5** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
Golgi apparatus	IBA IDA
Golgi cisterna membrane	IEA
Golgi membrane	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IEA
galactosyltransferase activity	IBA
metal ion binding	IEA
N-acetyllactosamine synthase activity	IEA
lactose synthase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

hexosyltransferase activity [inference]

galactosyltransferase activity

UDP-galactosyltransferase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000117411

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg078

Gene Symbol

B4GALT2

Reactions

Displaying **all 3** entries
Donor	Acceptor	Product	Reference
UDP-Gal	G49108TO	G00055MO	9405390
UDP-Gal	G71817IG	G81756OO	9435216
UDP-Gal	G76294XX	G80524SB	9435216

Displaying **all 5** entries
Donor	Acceptor	Product	Reference
UDP-Gal	G14651SS	G93379VC	9405390
UDP-Gal	G49108TO	G00055MO	9405390 9435216
UDP-Gal	G87229LF	G50361AJ	9435216
UDP-Gal	G71817IG	G81756OO	9435216
UDP-Gal	G76294XX	G80524SB	9435216

Displaying **all 6** entries
Donor	Acceptor	Reference
UDP-Gal	G61418DU	9405390
UDP-Gal	G49108TO	9405390
UDP-Gal	G68544GH	9405390
UDP-Gal	G33476GF	9405390
UDP-Gal	G57321FI	9405390
UDP-Gal	G65889KE	9405390

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Rattus norvegicus	XP_242992	XM_242992
Drosophila melanogaster	NP_610946	NM_137102
Mus musculus	NP_059073	NM_017377

KEGG BRITE Database

Orthology

K07967

Name

beta-1,4-galactosyltransferase 2 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]

References

11588157

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05989	2.4.1.38	G80858MF	G78059CC
R05977	2.4.1.- 2.4.1.275	G06239NA	G58896AZ

Rhea

RHEA:17745

N-acetyl-D-glucosamine + UDP-α-D-galactose

H⁺ + UDP + β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine

Enzyme

2.4.1.90

PMID

RHEA:22932

an N-acetyl-β-D-glucosaminyl derivative + UDP-α-D-galactose

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.38

PMID

RHEA:12404

D-glucose + UDP-α-D-galactose

H⁺ + lactose + UDP

Enzyme

2.4.1.22

PMID

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:1094	attention deficit hyperactivity disorder	DisGeNET
DOID:13328	diabetic cataract	DisGeNET
DOID:4362	cervical cancer	DisGeNET
DOID:5672	large intestine cancer	DisGeNET
DOID:8947	diabetic retinopathy	DisGeNET
DOID:9256	colorectal cancer	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002947
Gene Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	190668	WB:WBGene00000269
Drosophila melanogaster	36585	FB:FBgn0027538
Callorhinchus milii	103182791		CALMI25766
Latimeria chalumnae	102350195		LATCH10849
Danio rerio	100148828	ZFIN:ZDB-GENE-070912-258	DANRE28898
Astyanax mexicanus	103033307		ASTMX13861
Ictalurus punctatus	108267387		ICTPU31961
Electrophorus electricus	113584665		ELEEL34084
Salmo salar	106569086		SALSA70968
Salmo salar	106599387		SALSA20128

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements