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Standards Ontologies Notations
Disintegrin and metalloproteinase domain-containing protein 10

Summary
UniProt ID
O14672
Gene Symbol
  • ADAM10
  • KUZ
  • MADM
Organism
Homo sapiens (human)
External Links
GlyConnect
GlyGen
O14672
PubChem
O14672
The O-GlcNAc Database
O14672
RaftProt
O14672
O-GlcNAcAtlas
O14672
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Alzheimer disease
  • Amyloidosis
  • Cell junction
  • Cell membrane
  • Cell projection
  • Cleavage on pair of basic residues
  • Cytoplasm
  • Cytoplasmic vesicle
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Golgi apparatus
  • Metal-binding
  • Metalloprotease
  • Neurodegeneration
  • Notch signaling pathway
  • Phosphoprotein
  • Reference proteome
  • SH3-binding
  • Signal
  • Transmembrane helix
  • Zinc
  • Zymogen
Gene Ontology (GO)
Displaying entries 11 - 12 of 12 in total
GO Term
endopeptidase activity
metalloendopeptidase activity
Annotation information from UniProt.
Sequence
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 15 in total
Position Description PubMed ID GlyTouCan ID Source
31
36
37
124
130
194
248
267 N-linked (GlcNAc...) asparagine
269
278 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 16 in total
Pathway Name Organism
Activated NOTCH1 Transmits Signal to the Nucleus Homo sapiens
Amyloid fiber formation Homo sapiens
Collagen degradation Homo sapiens
Constitutive Signaling by NOTCH1 HD Domain Mutants Homo sapiens
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Homo sapiens
Constitutive Signaling by NOTCH1 PEST Domain Mutants Homo sapiens
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Homo sapiens
Degradation of the extracellular matrix Homo sapiens
EPH-ephrin mediated repulsion of cells Homo sapiens
NOTCH2 Activation and Transmission of Signal to the Nucleus Homo sapiens
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024