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Repository for lectin-assisted multimodality data
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MIRAGE
DNA repair protein RAD51 homolog 3
Summary
- UniProt ID
- O43502
- Gene Symbol
-
- RAD51C
- RAD51L2
- Gene ID
- 5889
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cytoplasm
- DNA recombination
- DNA repair
- DNA-binding
- Disease variant
- Fanconi anemia
- Mitochondrion
- Nucleus
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| Rad51C-XRCC3 complex |
| GO Term |
|---|
| crossover junction DNA endonuclease activity |
| DNA binding |
| ATP binding |
| ATP-dependent DNA damage sensor activity |
Sequence
MRGKTFRFEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWDRKQRLATLYKSPSQKECTVLFQIKPQGFRDTVVTSACSLQTEGSLSTRKRSRDPEEEL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 60 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | Homo sapiens |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | Homo sapiens |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | Homo sapiens |
| Factors involved in megakaryocyte development and platelet production | Homo sapiens |
| HDR through Homologous Recombination (HRR) | Homo sapiens |
| Homologous DNA Pairing and Strand Exchange | Homo sapiens |
| Impaired BRCA2 binding to PALB2 | Homo sapiens |
| Meiotic recombination | Homo sapiens |
| Presynaptic phase of homologous DNA pairing and strand exchange | Homo sapiens |
| Resolution of D-loop Structures through Holliday Junction Intermediates | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111096 | Fanconi anemia complementation group O | |
| DOID:5683 | hereditary breast ovarian cancer syndrome |
