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Repository for lectin-assisted multimodality data
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MIRAGE
Coagulation factor IX
Summary
- UniProt ID
- P00740
- Gene Symbol
-
- F9
- Gene ID
- 2158
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P00740
- PubChem
- P00740
- The Human Metabolome Database
- HMDBP01730
- Re-Glyco
- P00740
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hemophilia
- Hydroxylation
- Magnesium
- Metal-binding
- Pharmaceutical
- Phosphoprotein
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sulfation
- Thrombophilia
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| plasma membrane |
| collagen-containing extracellular matrix |
| endoplasmic reticulum lumen |
| Golgi lumen |
| extracellular exosome |
| GO Term |
|---|
| zymogen activation |
| proteolysis |
| blood coagulation |
| GO Term |
|---|
| serine-type endopeptidase activity |
| calcium ion binding |
| metal ion binding |
| endopeptidase activity |
Sequence
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 85 | O-linked (GalNAc...) threonine | |||
| 90 |
|
|||
| 99 | O-linked (Glc...) serine | |||
| 107 | O-linked (Fuc...) serine | |||
| 203 | N-linked (GlcNAc...) asparagine |
|
||
| 205 | O-linked (GalNAc...) threonine; alternate | |||
| 213 | N-linked (GlcNAc...) asparagine |
|
||
| 215 | O-linked (GalNAc...) threonine | |||
| 218 |
|
|||
| 225 | O-linked (GalNAc...) threonine |
G70649KP
G10651WD
G45637XA
G81006GJ
G57321FI
G24693UW
G45127HA
G31189KC
G38979OV
G50236GJ
G70593HA
G27608TI
G76163CP
G96881BQ
G43417UB
G29068FM
G18717LR
G74722FL
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective F9 activation | Homo sapiens |
| Defective F9 secretion | Homo sapiens |
| Defective F9 variant does not activate FX | Homo sapiens |
| Defective cofactor function of FVIIIa variant | Homo sapiens |
| Defective factor IX causes thrombophilia | Homo sapiens |
| Defective gamma-carboxylation of F9 | Homo sapiens |
| Extrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
| Gamma-carboxylation of protein precursors | Homo sapiens |
| Intrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
| Protein hydroxylation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080839 | X-linked warfarin sensitivity | |
| DOID:0111899 | X-linked thrombophilia due to factor IX defect | |
| DOID:12259 | hemophilia B |
