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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Low-density lipoprotein receptor
Summary
- UniProt ID
- P01130
- Gene Symbol
-
- LDLR
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Cholesterol metabolism
- Coated pit
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Endocytosis
- Endosome
- Glycoprotein
- Golgi apparatus
- Host cell receptor for virus entry
- Host-virus interaction
- LDL
- Lipid transport
- Lysosome
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| regulation of protein metabolic process |
| lipoprotein catabolic process |
| artery morphogenesis |
| negative regulation of protein metabolic process |
| negative regulation of astrocyte activation |
| cellular response to fatty acid |
| GO Term |
|---|
| sorting endosome |
| PCSK9-LDLR complex |
| basolateral plasma membrane |
| clathrin-coated endocytic vesicle membrane |
| apical part of cell |
| endosome membrane |
| early endosome |
| late endosome |
| clathrin-coated pit |
| external side of plasma membrane |
Sequence
MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 97 | N-linked (GlcNAc...) asparagine | |||
| 108 |
|
|||
| 156 | N-linked (GlcNAc...) asparagine |
|
||
| 235 |
|
|||
| 272 | N-linked (GlcNAc...) asparagine | |||
| 515 | N-linked (GlcNAc...) asparagine | |||
| 657 | N-linked (GlcNAc...) asparagine | |||
| 665 |
|
|||
| 710 |
|
|||
| 721 |
|
G31852PQ
G43417UB
G57321FI
G11629QQ
G83229XP
G25451PN
G84452RH
G43769HG
G37881RL
G47012YE
G45395BF
G75983OB
G00912UN
G96430BV
G41071NU
G70619PT
G00406II
G48414YA
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cargo recognition for clathrin-mediated endocytosis | Homo sapiens |
| Chylomicron clearance | Homo sapiens |
| Clathrin-mediated endocytosis | Homo sapiens |
| LDL clearance | Homo sapiens |
| Retinoid metabolism and transport | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
