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MIRAGE
Immunoglobulin heavy constant epsilon

Summary
UniProt ID
P01854
Gene Symbol
  • IGHE
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P01854
PubChem
P01854
Re-Glyco
P01854
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Immunoglobulin
  • Immunoglobulin domain
  • Inflammatory response
  • Reference proteome
  • Repeat
  • Secreted
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 6 entries
GO Term
extracellular region
extracellular space
plasma membrane
immunoglobulin complex, circulating
IgE immunoglobulin complex
IgE B cell receptor complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
immunoglobulin receptor binding
antigen binding
Annotation information from UniProt.
Sequence
ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTDWVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGLAGGSAQSQRAPDRVLCHSGQQQGLPRAAGGSVPHPRCHCGAGRADWPGPPELDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAAITLLMVQRFLSATRQGRPQTSLDYTNVLQPHA
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 8 entries
Position Description PubMed ID GlyTouCan ID Source
21 N-linked (GlcNAc...) asparagine
49 N-linked (GlcNAc...) asparagine
99 N-linked (GlcNAc...) asparagine
146 N-linked (GlcNAc...) asparagine
252 N-linked (GlcNAc...) asparagine
264 N-linked (GlcNAc...) asparagine
275 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 6 entries
Pathway Name Organism
FCERI mediated Ca+2 mobilization Homo sapiens
FCERI mediated MAPK activation Homo sapiens
FCERI mediated NF-kB activation Homo sapiens
Fc epsilon receptor (FCERI) signaling Homo sapiens
Interleukin-4 and Interleukin-13 signaling Homo sapiens
Role of LAT2/NTAL/LAB on calcium mobilization Homo sapiens
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025