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MIRAGE
Fibrinogen beta chain

Summary
UniProt ID
P02675
Gene Symbol
  • FGB
Gene ID
2244
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011304
GlyConnect
GlyGen
P02675
PubChem
P02675
The Human Metabolome Database
HMDBP13514
RaftProt
P02675
Re-Glyco
P02675
Annotation
Keyword
  • 3D-structure
  • Adaptive immunity
  • Blood coagulation
  • Coiled coil
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Innate immunity
  • Pyrrolidone carboxylic acid
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying entries 1 - 10 of 15 in total
GO Term
extracellular vesicle
extracellular region
fibrinogen complex
extracellular space
plasma membrane
cell cortex
synapse
collagen-containing extracellular matrix
endoplasmic reticulum
external side of plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 9 entries
Position Description PubMed ID GlyTouCan ID Source
58
108
214
251
314
360
394 N-linked (GlcNAc...) asparagine
435
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 18 in total
Pathway Name Organism
Common Pathway of Fibrin Clot Formation Homo sapiens
ER-Phagosome pathway Homo sapiens
GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens
IRAK4 deficiency (TLR2/4) Homo sapiens
Integrin cell surface interactions Homo sapiens
Integrin signaling Homo sapiens
MAP2K and MAPK activation Homo sapiens
MyD88 deficiency (TLR2/4) Homo sapiens
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Homo sapiens
Paradoxical activation of RAF signaling by kinase inactive BRAF Homo sapiens
Disease
Displaying all 7 entries
DO ID Disease Name Source
DOID:0060903 thrombosis
DOID:1287 cardiovascular system disease
DOID:2236 congenital afibrinogenemia
DOID:3393 coronary artery disease
DOID:3407 carotid artery disease
DOID:5844 myocardial infarction
DOID:783 end stage renal disease
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025