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Poly [ADP-ribose] polymerase 1

Summary

UniProt ID

P11103

Gene Symbol

Parp1
Adprp
Adprt
Adprt1

Organism

Mus musculus (house mouse)

External Links

GlyGen: P11103
PubChem: P11103
The O-GlcNAc Database: P11103

Annotation

Keyword

ADP-ribosylation
Acetylation
Allosteric enzyme
Alternative initiation
Apoptosis
Chromosome
Cytoplasm
DNA repair
DNA-binding
Direct protein sequencing
Glycosyltransferase
Innate immunity
Isopeptide bond
NAD
Nucleotidyltransferase
Nucleus
Phosphoprotein
Reference proteome
Repeat
S-nitrosylation
Transcription regulation
Ubl conjugation
Zinc-finger

Gene Ontology (GO)

Displaying entries **1 - 10** of 48 in total

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GO Term
positive regulation of cardiac muscle hypertrophy
signal transduction involved in regulation of gene expression
negative regulation of interleukin-17 production
regulation of protein localization
cellular response to oxidative stress
cellular response to superoxide
positive regulation of protein localization to nucleus
negative regulation of adipose tissue development
positive regulation of myofibroblast differentiation
voluntary musculoskeletal movement

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GO Term
chromatin
nucleus
nucleolus
cytoplasm
protein-containing complex
site of double-strand break
site of DNA damage
nuclear replication fork
mitochondrion
cytosol

Displaying entries **1 - 10** of 21 in total

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GO Term
zinc ion binding
histone deacetylase binding
R-SMAD binding
NAD+-protein-serine ADP-ribosyltransferase activity
NAD+- protein-aspartate ADP-ribosyltransferase activity
NAD+-protein-glutamate ADP-ribosyltransferase activity
NAD+-protein-tyrosine ADP-ribosyltransferase activity
NAD+-protein-histidine ADP-ribosyltransferase activity
NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity
NAD binding

Annotation information from UniProt.

Sequence

MAEASERLYRVQYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGQSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVAGKGQDGSGGKAEKTLGDFAAEYAKSNRSMCKGCLEKIEKGQMRLSKKMVDPEKPQLGMIDRWYHPTCFVKKRDELGFRPEYSASQLKGFSLLSAEDKEALKKQLPAIKNEGKRKGDEVDGTDEVAKKKSRKETDKYSKLEKALKAQNELIWNIKDELKKACSTNDLKELLIFNQQQVPSGESAILDRVADGMAFGALLPCKECSGQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREISYLKKLKVKKQDRIFPPESSAPITVHWPLSVTSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAVIEKLGGKLTGSANKASLCISIKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQDLLSAHSLSPWGAEVKAEPGEVVAPRGKSAAPSKKSKGCFKEEGVNKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKESRYWIFRSWGRLGTVIGSNKLEQMPSKEEAVEQFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVKPGTKSKLPKPVQELVGMIFDVDSMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQPVSQGSSESQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLIMLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSASITLEGVEVPLGTGIPSGVNDTALLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
121			G44613TH	GlyGen
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
DNA Damage Recognition in GG-NER	Mus musculus
Downregulation of SMAD2/3:SMAD4 transcriptional activity	Mus musculus
Dual Incision in GG-NER	Mus musculus
Formation of Incision Complex in GG-NER	Mus musculus
HDR through MMEJ (alt-NHEJ)	Mus musculus
POLB-Dependent Long Patch Base Excision Repair	Mus musculus
SUMOylation of DNA damage response and repair proteins	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements