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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Summary
- UniProt ID
- P19174
- Gene Symbol
-
- PLCG1
- PLC1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P19174
- PubChem
- P19174
- The Human Metabolome Database
- HMDBP00244
- The O-GlcNAc Database
- P19174
- O-GlcNAcAtlas
- P19174
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Calcium
- Cell projection
- Disease variant
- Host-virus interaction
- Hydrolase
- Lipid degradation
- Metal-binding
- Phosphoprotein
- Reference proteome
- Repeat
- SH2 domain
- SH3 domain
- Transducer
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| plasma membrane |
| cell-cell junction |
| cell projection |
| Schaffer collateral - CA1 synapse |
| glutamatergic synapse |
| lamellipodium |
| cytosol |
| ruffle |
| COP9 signalosome |
Sequence
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 63 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Phospholipase C-mediated cascade; FGFR4 | Homo sapiens |
| RET signaling | Homo sapiens |
| Role of phospholipids in phagocytosis | Homo sapiens |
| Role of second messengers in netrin-1 signaling | Homo sapiens |
| Signaling by ALK | Homo sapiens |
| Signaling by ALK fusions and activated point mutants | Homo sapiens |
| Signaling by ERBB2 ECD mutants | Homo sapiens |
| Signaling by ERBB2 KD Mutants | Homo sapiens |
| Signaling by ERBB2 TMD/JMD mutants | Homo sapiens |
| Signaling by FGFR1 in disease | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:2348 | arteriosclerotic cardiovascular disease | |
| DOID:235 | colonic benign neoplasm | |
| DOID:2394 | ovarian cancer | |
| DOID:268 | liver angiosarcoma | |
| DOID:2772 | irritant dermatitis | |
| DOID:2841 | asthma | |
| DOID:2848 | obsolete melancholia | |
| DOID:2914 | immune system disease | |
| DOID:299 | adenocarcinoma | |
| DOID:305 | carcinoma |
