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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Brain-derived neurotrophic factor
Summary
- UniProt ID
- P21237
- Gene Symbol
-
- Bdnf
- Organism
- Mus musculus (house mouse)
External Links
- PubChem
- P21237
Annotation
- Keyword
-
- Alternative splicing
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Growth factor
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| hippocampal mossy fiber to CA3 synapse |
| glutamatergic synapse |
| neuronal dense core vesicle |
| terminal bouton |
| endoplasmic reticulum lumen |
| perinuclear region of cytoplasm |
| extracellular region |
| extracellular space |
| cytoplasm |
| secretory granule |
| GO Term |
|---|
| nerve growth factor receptor binding |
| neurotrophin TRKB receptor binding |
| growth factor activity |
Sequence
MTILFLTMVISYFGCMKAAPMKEVNVHGQGNLAYPGVRTHGTLESVNGPRAGSRGLTTTSLADTFEHVIEELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 123 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NTRK2 signals through FRS2 and FRS3 | Mus musculus |
| Activated NTRK2 signals through PLCG1 | Mus musculus |
| NTRK2 activates RAC1 | Mus musculus |
| PI3K/AKT Signaling | Mus musculus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Mus musculus |
