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MIRAGE
Tyrosine-protein kinase JAK1

Summary
UniProt ID
P23458
Gene Symbol
  • JAK1
  • JAK1A
  • JAK1B
Gene ID
3716
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P23458
PubChem
P23458
The Human Metabolome Database
HMDBP01309
RaftProt
P23458
Re-Glyco
P23458
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Disease variant
  • Magnesium
  • Membrane
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • SH2 domain
  • Tyrosine-protein kinase
  • Ubl conjugation
Gene Ontology (GO)
Displaying all 9 entries
GO Term
nucleus
cytoplasm
cytoskeleton
plasma membrane
endosome
cytosol
focal adhesion
cytoplasmic side of plasma membrane
extrinsic component of cytoplasmic side of plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
769
814
1095
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 21 - 29 of 29 in total
Pathway Name Organism
MAPK1 (ERK2) activation Homo sapiens
MAPK3 (ERK1) activation Homo sapiens
Other interleukin signaling Homo sapiens
Potential therapeutics for SARS Homo sapiens
RAF/MAP kinase cascade Homo sapiens
Regulation of IFNA/IFNB signaling Homo sapiens
Regulation of IFNG signaling Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses Homo sapiens
Signaling by CSF3 (G-CSF) Homo sapiens
Disease
Displaying all 9 entries
DO ID Disease Name Source
DOID:10283 prostate cancer
DOID:10534 stomach cancer
DOID:1380 endometrial cancer
DOID:2394 ovarian cancer
DOID:3908 lung non-small cell carcinoma
DOID:4074 pancreatic adenocarcinoma
DOID:5603 T-cell acute lymphoblastic leukemia
DOID:684 hepatocellular carcinoma
DOID:9256 colorectal cancer
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025