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Cyclin-dependent kinase 2

Summary

UniProt ID

P24941

Gene Symbol

CDK2
CDKN2

Organism

Homo sapiens (human)

External Links

GlyGen: P24941
PubChem: P24941
The Human Metabolome Database: HMDBP01383
The O-GlcNAc Database: P24941

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cytoskeleton
DNA repair
Endosome
Magnesium
Meiosis
Metal-binding
Mitosis
Nucleus
Phosphoprotein
Reference proteome
S-nitrosylation
Serine/threonine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 10** of 30 in total

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GO Term
protein phosphorylation
signal transduction
regulation of mitotic cell cycle
positive regulation of cell population proliferation
response to organic substance
regulation of gene expression
regulation of G2/M transition of mitotic cell cycle
mitotic G1 DNA damage checkpoint signaling
centrosome duplication
positive regulation of DNA-templated DNA replication initiation

Displaying entries **1 - 10** of 19 in total

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GO Term
male germ cell nucleus
nucleus
nuclear envelope
cytoplasm
Cajal body
cyclin A1-CDK2 complex
cyclin A2-CDK2 complex
cyclin E1-CDK2 complex
cyclin E2-CDK2 complex
chromosome, telomeric region

Displaying **all 8** entries
GO Term
protein serine kinase activity
protein serine/threonine kinase activity
protein domain specific binding
cyclin binding
magnesium ion binding
cyclin-dependent protein serine/threonine kinase activity
cyclin-dependent protein kinase activity
ATP binding

Annotation information from UniProt.

Sequence

MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **21 - 27** of 27 in total

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Pathway Name	Organism
Regulation of TP53 Degradation	Homo sapiens
SCF(Skp2)-mediated degradation of p27/p21	Homo sapiens
Senescence-Associated Secretory Phenotype (SASP)	Homo sapiens
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	Homo sapiens
Telomere Extension By Telomerase	Homo sapiens
Transcriptional regulation of granulopoiesis	Homo sapiens
p53-Dependent G1 DNA Damage Response	Homo sapiens