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Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Summary
- UniProt ID
- P30153
- Gene Symbol
-
- PPP2R1A
- Gene ID
- 5518
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Cell membrane
- Cell projection
- Centromere
- Chromosome
- Chromosome partition
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Host-virus interaction
- Intellectual disability
- Nucleus
- Reference proteome
- Repeat
- Gene Ontology (GO)
| GO Term |
|---|
| microtubule cytoskeleton |
| lateral plasma membrane |
| extracellular exosome |
| glutamatergic synapse |
| protein phosphatase type 2A complex |
| GO Term |
|---|
| protein serine/threonine phosphatase activity |
| protein heterodimerization activity |
| protein phosphatase regulator activity |
| protein antigen binding |
Sequence
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 553 |
|
|||
| 555 |
|
G62765YT
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| PP2A-mediated dephosphorylation of key metabolic factors | Homo sapiens |
| Platelet sensitization by LDL | Homo sapiens |
| RAF activation | Homo sapiens |
| RHO GTPases Activate Formins | Homo sapiens |
| Recruitment of NuMA to mitotic centrosomes | Homo sapiens |
| Recruitment of mitotic centrosome proteins and complexes | Homo sapiens |
| Regulation of PLK1 Activity at G2/M Transition | Homo sapiens |
| Regulation of TP53 Degradation | Homo sapiens |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | Homo sapiens |
| Resolution of Sister Chromatid Cohesion | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070066 | autosomal dominant intellectual developmental disorder 36 |
