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MIRAGE
RAC-alpha serine/threonine-protein kinase
Summary
- UniProt ID
- P31749
- Gene Symbol
-
- AKT1
- PKB
- RAC
- Gene ID
- 207
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Apoptosis
- Cell membrane
- Cytoplasm
- Developmental protein
- Disease variant
- Disulfide bond
- Glucose metabolism
- Glycogen biosynthesis
- Glycogen metabolism
- Glycoprotein
- Isopeptide bond
- Mitochondrion
- Neurogenesis
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Serine/threonine-protein kinase
- Sugar transport
- Translation regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| postsynapse |
| cytosol |
| mitochondrial intermembrane space |
| spindle |
| microtubule cytoskeleton |
| lamellipodium |
| ciliary basal body |
| nucleus |
| cytoplasm |
| plasma membrane |
| GO Term |
|---|
| DNA-dependent protein kinase activity |
| histone H2AXS139 kinase activity |
| histone H2BS14 kinase activity |
| histone H2BS36 kinase activity |
| histone H3T45 kinase activity |
| histone H3S57 kinase activity |
| kinase activity |
Sequence
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 126 | O-linked (GlcNAc) serine; alternate | |||
| 129 | O-linked (GlcNAc) serine; alternate | |||
| 305 | O-linked (GlcNAc) threonine | |||
| 308 |
|
|||
| 312 | O-linked (GlcNAc) threonine | |||
| 473 | O-linked (GlcNAc) serine; alternate |
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Deactivation of the beta-catenin transactivating complex | Homo sapiens |
| Downregulation of ERBB2:ERBB3 signaling | Homo sapiens |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | Homo sapiens |
| Extra-nuclear estrogen signaling | Homo sapiens |
| FLT3 Signaling | Homo sapiens |
| G beta:gamma signalling through PI3Kgamma | Homo sapiens |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | Homo sapiens |
| Integrin signaling | Homo sapiens |
| Interleukin-4 and Interleukin-13 signaling | Homo sapiens |
| KEAP1-NFE2L2 pathway | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:0081002 | Cowden syndrome 6 | |
| DOID:10283 | prostate cancer | |
| DOID:1107 | esophageal carcinoma | |
| DOID:13482 | Proteus syndrome | |
| DOID:14330 | Parkinson's disease | |
| DOID:1612 | breast cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:219 | colon cancer | |
| DOID:2394 | ovarian cancer |
