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Dual specificity mitogen-activated protein kinase kinase 1

Summary

UniProt ID

P31938

Gene Symbol

Map2k1
Mek1
Prkmk1

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003563
GlyGen: P31938
PubChem: P31938
The O-GlcNAc Database: P31938
RaftProt: P31938

Annotation

Keyword

ATP-binding
Cytoskeleton
Direct protein sequencing
Membrane
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 10** of 55 in total

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GO Term
response to oxidative stress
heart development
negative regulation of cell population proliferation
insulin receptor signaling pathway
positive regulation of gene expression
negative regulation of gene expression
phosphorylation
neuron differentiation
keratinocyte differentiation
positive regulation of cell migration

Displaying entries **11 - 18** of 18 in total

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GO Term
perinuclear region of cytoplasm
Golgi apparatus
plasma membrane
cell cortex
axon
dendrite
dendrite cytoplasm
glutamatergic synapse

Displaying entries **1 - 10** of 13 in total

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GO Term
protein serine/threonine kinase activity
protein tyrosine kinase activity
protein-containing complex binding
protein kinase binding
protein serine/threonine kinase activator activity
mitogen-activated protein kinase kinase kinase binding
MAP kinase kinase activity
protein serine/threonine/tyrosine kinase activity
MAP-kinase scaffold activity
ATP binding

Annotation information from UniProt.

Sequence

MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
21			G40926MX	GlycoProtDB GlyGen
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Frs2-mediated activation	Mus musculus
MAP2K and MAPK activation	Mus musculus
MAPK3 (ERK1) activation	Mus musculus
Negative feedback regulation of MAPK pathway	Mus musculus
RAF activation	Mus musculus
Signal transduction by L1	Mus musculus