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MIRAGE
Receptor-type tyrosine-protein kinase FLT3
Summary
- UniProt ID
- P36888
- Gene Symbol
-
- CD135
- FLK2
- FLT3
- STK1
- Gene ID
- 2322
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P36888
- PubChem
- P36888
- The Human Metabolome Database
- HMDBP01189
- Re-Glyco
- P36888
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Immunoglobulin domain
- Phosphoprotein
- Proto-oncogene
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| receptor complex |
| endoplasmic reticulum |
| endoplasmic reticulum lumen |
| endosome membrane |
Sequence
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 43 | N-linked (GlcNAc...) asparagine |
|
||
| 100 | N-linked (GlcNAc...) asparagine |
|
||
| 151 | N-linked (GlcNAc...) asparagine |
|
||
| 306 | N-linked (GlcNAc...) asparagine |
|
||
| 323 | N-linked (GlcNAc...) asparagine | |||
| 351 | N-linked (GlcNAc...) asparagine |
|
||
| 354 | N-linked (GlcNAc...) asparagine |
|
||
| 473 |
|
|
||
| 502 |
|
|
||
| 541 | N-linked (GlcNAc...) asparagine |
|
G80920RR
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| RAF/MAP kinase cascade | Homo sapiens |
| STAT5 Activation | Homo sapiens |
| STAT5 activation downstream of FLT3 ITD mutants | Homo sapiens |
| Signaling by FLT3 ITD and TKD mutants | Homo sapiens |
| crenolanib-resistant FLT3 mutants | Homo sapiens |
| gilteritinib-resistant FLT3 mutants | Homo sapiens |
| lestaurtinib-resistant FLT3 mutants | Homo sapiens |
| linifanib-resistant FLT3 mutants | Homo sapiens |
| midostaurin-resistant FLT3 mutants | Homo sapiens |
| pexidartinib-resistant FLT3 mutants | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:0081082 | acute myelomonocytic leukemia | |
| DOID:10283 | prostate cancer | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:9119 | acute myeloid leukemia | |
| DOID:9952 | acute lymphoblastic leukemia |
