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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Summary

UniProt ID

P42338

Gene Symbol

PIK3CB
PIK3C1

Organism

Homo sapiens (human)

External Links

PubChem: P42338
The Human Metabolome Database: HMDBP01208
The O-GlcNAc Database: P42338

Annotation

Keyword

ATP-binding
Autophagy
Cell adhesion
Cytoplasm
Endocytosis
Kinase
Lipid metabolism
Nucleus
Phosphoprotein
Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 10** of 34 in total

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GO Term
positive regulation of neutrophil apoptotic process
phosphatidylinositol-3-phosphate biosynthetic process
negative regulation of sprouting angiogenesis
regulation of clathrin-dependent endocytosis
regulation of cell-matrix adhesion
response to ischemia
autophagy
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of Rac protein signal transduction
phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying **all 10** entries
GO Term
midbody
nucleoplasm
cytosol
nucleus
nucleolus
cytoplasm
plasma membrane
intracellular membrane-bounded organelle
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA

Displaying **all 7** entries
GO Term
1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
ATP binding
insulin receptor substrate binding
protein serine kinase activity
kinase activity

Annotation information from UniProt.

Sequence

MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	GlyTouCan ID	Source
478	G49108TO	The O-GlcNAc Database
481	G49108TO	The O-GlcNAc Database
485	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 30 in total

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Pathway Name	Organism
Constitutive Signaling by Aberrant PI3K in Cancer	Homo sapiens
DAP12 signaling	Homo sapiens
Downstream TCR signaling	Homo sapiens
Downstream signal transduction	Homo sapiens
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Homo sapiens
GPVI-mediated activation cascade	Homo sapiens
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Homo sapiens
IRS-mediated signalling	Homo sapiens
Interleukin receptor SHC signaling	Homo sapiens
Interleukin-3, Interleukin-5 and GM-CSF signaling	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements