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Standards Ontologies Notations
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MIRAGE
Interleukin-3, Interleukin-5 and GM-CSF signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p-STAT5p-STAT5 dimerp-STAT5 dimerIL3RBIL3RB:JAK2JAK2CSF2RAGM-CSF:GM-CSF receptor alpha subunitCSF2GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2IL5IL5 homodimerIL5 homodimer:IL5RAIL5RAIL5 homodimer:IL5RA:Common beta chain:JAK2IL3IL3:IL3RAIL3RAIL3:IL3RA:IL3RB:JAK2High affinity binding complexes of interleukin receptors using the Common beta chainHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2ATPADPSTAT5High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-BcHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1SHCHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1VAV1TEC:VAV1TECSHP1,SHP2High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2SHP2SHP2:GRB2Ash-LHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-BcYWHAZHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zetaHigh affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ksp85-containing Class 1A PI3Ks
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025