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Protein jagged-1
Summary
- UniProt ID
- P78504
- Gene Symbol
-
- JAG1
- JAGL1
- Gene ID
- 182
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011757
- GlyGen
- P78504
- PubChem
- P78504
- Re-Glyco
- P78504
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cell membrane
- Charcot-Marie-Tooth disease
- Deafness
- Developmental protein
- Disease variant
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Neurodegeneration
- Notch signaling pathway
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| membrane |
| adherens junction |
| apical plasma membrane |
| extracellular region |
| plasma membrane |
| GO Term |
|---|
| molecular adaptor activity |
| Notch binding |
| calcium ion binding |
| structural molecule activity |
| phospholipid binding |
| growth factor activity |
Sequence
MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQDNRDLESAQSLNRMEYIV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 86 |
|
|||
| 143 | N-linked (GlcNAc...) asparagine |
|
||
| 217 | N-linked (GlcNAc...) asparagine | |||
| 370 |
|
|
||
| 382 | N-linked (GlcNAc...) asparagine |
|
||
| 559 | N-linked (GlcNAc...) asparagine |
|
||
| 585 |
|
|
||
| 597 |
|
|
||
| 745 | N-linked (GlcNAc...) asparagine |
|
||
| 960 | N-linked (GlcNAc...) asparagine |
|
G57321FI
G27058EU
G41071NU
G80920RR
G42124LM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | Homo sapiens |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| Nephron development | Homo sapiens |
| RAC1 GTPase cycle | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | |
| DOID:1682 | congenital heart disease | |
| DOID:2377 | multiple sclerosis | |
| DOID:6419 | tetralogy of Fallot | |
| DOID:9245 | Alagille syndrome |
