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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Summary

UniProt ID

Q62077

Gene Symbol

Plcg1
Plcg-1

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q62077
PubChem: Q62077

Annotation

Keyword

Acetylation
Calcium
Cell projection
Hydrolase
Lipid degradation
Metal-binding
Phosphoprotein
Reference proteome
Repeat
SH2 domain
SH3 domain
Transducer
Ubl conjugation

Gene Ontology (GO)

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GO Term
modulation of chemical synaptic transmission
positive regulation of vascular endothelial cell proliferation
positive regulation of endothelial cell apoptotic process
phosphatidylinositol catabolic process
T cell receptor signaling pathway
release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
phosphatidylinositol metabolic process
epidermal growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling

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GO Term
Schaffer collateral - CA1 synapse
cytoplasm
plasma membrane
cell-cell junction
glutamatergic synapse
lamellipodium
clathrin-coated vesicle
cytosol
ruffle
COP9 signalosome

Displaying **all 10** entries
GO Term
calcium ion binding
calcium-dependent phospholipase C activity
phosphoprotein binding
phosphatidylinositol phospholipase C activity
phospholipase C activity
guanyl-nucleotide exchange factor activity
insulin receptor binding
neurotrophin TRKA receptor binding
receptor tyrosine kinase binding
glutamate receptor binding

Annotation information from UniProt.

Sequence

MAGVATPCANGCGPGAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNALRTGERPEHCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLRRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASSSTELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAVLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGISLRERASDASSQLFHVRAREGSFEARYQQPFEDFRISQEHLADHFDSRERSTSDGPSSATNLIEDPLHDKLWKCSL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Activated NTRK2 signals through PLCG1	Mus musculus
Activated NTRK3 signals through PLCG1	Mus musculus
DAP12 signaling	Mus musculus
Downstream signal transduction	Mus musculus
EGFR interacts with phospholipase C-gamma	Mus musculus
FCERI mediated Ca+2 mobilization	Mus musculus
FCERI mediated MAPK activation	Mus musculus
Generation of second messenger molecules	Mus musculus
ISG15 antiviral mechanism	Mus musculus
PECAM1 interactions	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements